Abstract
From 1995-1999, a nation-wide study of Langerhans cell histiocytosis (LCH) in children less than 15 years old was conducted by the Taiwan Pediatric Oncology Group. The demographic and clinical data of 55 cases were analyzed. Thirty-two cases presented from the beginning of 1997 to the end of 1998, when the most severe El Niño in the century occurred. The incidence was higher than expected during this El Niño period (32 cases versus 22 cases, p=0.003). During 1997-98, most LCH was diagnosed in summer (n=15), autumn (n=8), and winter (n=8) but rarely in spring (n=1); coincidentally, rainfall was least in winter but peaked in summer. During 1997-98, the most significant increase occurred in the polyostotic LCH subcategory (p=0.017), with younger ages at diagnosis (p=0.039). The incidence of LCH cytopenia, fever, and diseases of the skin, liver, spleen or other organs did not differ significantly. Local treatment modality, disseminated diseases and diagnosis during the El Niño of 1997-98 were independent risk factors predicting the recurrence or progression of LCH. Our findings suggest that particular infections or other environmental factors associated with El Niño might be related to the etiology of childhood LCH.
| Original language | English |
|---|---|
| Pages (from-to) | 14-20 |
| Number of pages | 7 |
| Journal | Acta Paediatrica Taiwanica |
| Volume | 44 |
| Issue number | 1 |
| Publication status | Published - Jan 2003 |
| Externally published | Yes |
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Keywords
- Children
- El Niño
- Langerhans cell histiocytosis
- Taiwan
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Childhood Langerhans cell histiocytosis increased during El Niño 1997-98 : A report from the Taiwan Pediatric Oncology Group. / Chen, Rong Long; Lin, Kuo Sin; Chang, Wan Hui; Hsieh, Yuh Lin; Chen, Bow Wen; Jaing, Tang Her; Yang, Chao Ping; Hung, Iou Jih; Peng, Ching Tien; Shu, San Ging; Lu, Meng Yao; Jou, Sheng Tang; Lin, Kai Hsin; Lin, Dong Tsamn; Lin, Ming Tsan; Chen, Jiann Shiuh; Liu, His Che; Chen, Shu Huey; Liang, Der Cherng; Chiou, Shyh Shin; Chang, Tai Tsung; Sheen, Jiunn Ming; Hsiao, Chih Cheng; Cheng, Shin Nan; Lin, Jung Chung.
In: Acta Paediatrica Taiwanica, Vol. 44, No. 1, 01.2003, p. 14-20.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Childhood Langerhans cell histiocytosis increased during El Niño 1997-98
T2 - A report from the Taiwan Pediatric Oncology Group
AU - Chen, Rong Long
AU - Lin, Kuo Sin
AU - Chang, Wan Hui
AU - Hsieh, Yuh Lin
AU - Chen, Bow Wen
AU - Jaing, Tang Her
AU - Yang, Chao Ping
AU - Hung, Iou Jih
AU - Peng, Ching Tien
AU - Shu, San Ging
AU - Lu, Meng Yao
AU - Jou, Sheng Tang
AU - Lin, Kai Hsin
AU - Lin, Dong Tsamn
AU - Lin, Ming Tsan
AU - Chen, Jiann Shiuh
AU - Liu, His Che
AU - Chen, Shu Huey
AU - Liang, Der Cherng
AU - Chiou, Shyh Shin
AU - Chang, Tai Tsung
AU - Sheen, Jiunn Ming
AU - Hsiao, Chih Cheng
AU - Cheng, Shin Nan
AU - Lin, Jung Chung
PY - 2003/1
Y1 - 2003/1
N2 - From 1995-1999, a nation-wide study of Langerhans cell histiocytosis (LCH) in children less than 15 years old was conducted by the Taiwan Pediatric Oncology Group. The demographic and clinical data of 55 cases were analyzed. Thirty-two cases presented from the beginning of 1997 to the end of 1998, when the most severe El Niño in the century occurred. The incidence was higher than expected during this El Niño period (32 cases versus 22 cases, p=0.003). During 1997-98, most LCH was diagnosed in summer (n=15), autumn (n=8), and winter (n=8) but rarely in spring (n=1); coincidentally, rainfall was least in winter but peaked in summer. During 1997-98, the most significant increase occurred in the polyostotic LCH subcategory (p=0.017), with younger ages at diagnosis (p=0.039). The incidence of LCH cytopenia, fever, and diseases of the skin, liver, spleen or other organs did not differ significantly. Local treatment modality, disseminated diseases and diagnosis during the El Niño of 1997-98 were independent risk factors predicting the recurrence or progression of LCH. Our findings suggest that particular infections or other environmental factors associated with El Niño might be related to the etiology of childhood LCH.
AB - From 1995-1999, a nation-wide study of Langerhans cell histiocytosis (LCH) in children less than 15 years old was conducted by the Taiwan Pediatric Oncology Group. The demographic and clinical data of 55 cases were analyzed. Thirty-two cases presented from the beginning of 1997 to the end of 1998, when the most severe El Niño in the century occurred. The incidence was higher than expected during this El Niño period (32 cases versus 22 cases, p=0.003). During 1997-98, most LCH was diagnosed in summer (n=15), autumn (n=8), and winter (n=8) but rarely in spring (n=1); coincidentally, rainfall was least in winter but peaked in summer. During 1997-98, the most significant increase occurred in the polyostotic LCH subcategory (p=0.017), with younger ages at diagnosis (p=0.039). The incidence of LCH cytopenia, fever, and diseases of the skin, liver, spleen or other organs did not differ significantly. Local treatment modality, disseminated diseases and diagnosis during the El Niño of 1997-98 were independent risk factors predicting the recurrence or progression of LCH. Our findings suggest that particular infections or other environmental factors associated with El Niño might be related to the etiology of childhood LCH.
KW - Children
KW - El Niño
KW - Langerhans cell histiocytosis
KW - Taiwan
UR - http://www.scopus.com/inward/record.url?scp=0038185365&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038185365&partnerID=8YFLogxK
M3 - Article
C2 - 12800378
AN - SCOPUS:0038185365
VL - 44
SP - 14
EP - 20
JO - Pediatrics and Neonatology
JF - Pediatrics and Neonatology
SN - 1875-9572
IS - 1
ER -