Childhood Langerhans cell histiocytosis increased during El Niño 1997-98: A report from the Taiwan Pediatric Oncology Group

Rong Long Chen, Kuo Sin Lin, Wan Hui Chang, Yuh Lin Hsieh, Bow Wen Chen, Tang Her Jaing, Chao Ping Yang, Iou Jih Hung, Ching Tien Peng, San Ging Shu, Meng Yao Lu, Sheng Tang Jou, Kai Hsin Lin, Dong Tsamn Lin, Ming Tsan Lin, Jiann Shiuh Chen, His Che Liu, Shu Huey Chen, Der Cherng Liang, Shyh Shin ChiouTai Tsung Chang, Jiunn Ming Sheen, Chih Cheng Hsiao, Shin Nan Cheng, Jung Chung Lin

Research output: Contribution to journalArticle

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Abstract

From 1995-1999, a nation-wide study of Langerhans cell histiocytosis (LCH) in children less than 15 years old was conducted by the Taiwan Pediatric Oncology Group. The demographic and clinical data of 55 cases were analyzed. Thirty-two cases presented from the beginning of 1997 to the end of 1998, when the most severe El Niño in the century occurred. The incidence was higher than expected during this El Niño period (32 cases versus 22 cases, p=0.003). During 1997-98, most LCH was diagnosed in summer (n=15), autumn (n=8), and winter (n=8) but rarely in spring (n=1); coincidentally, rainfall was least in winter but peaked in summer. During 1997-98, the most significant increase occurred in the polyostotic LCH subcategory (p=0.017), with younger ages at diagnosis (p=0.039). The incidence of LCH cytopenia, fever, and diseases of the skin, liver, spleen or other organs did not differ significantly. Local treatment modality, disseminated diseases and diagnosis during the El Niño of 1997-98 were independent risk factors predicting the recurrence or progression of LCH. Our findings suggest that particular infections or other environmental factors associated with El Niño might be related to the etiology of childhood LCH.

Original languageEnglish
Pages (from-to)14-20
Number of pages7
JournalActa Paediatrica Taiwanica
Volume44
Issue number1
Publication statusPublished - Jan 2003
Externally publishedYes

Fingerprint

Langerhans Cell Histiocytosis
Taiwan
Pediatrics
Incidence
Skin Diseases
Liver Diseases
Fever
Spleen
Demography
Recurrence
Infection

Keywords

  • Children
  • El Niño
  • Langerhans cell histiocytosis
  • Taiwan

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Chen, R. L., Lin, K. S., Chang, W. H., Hsieh, Y. L., Chen, B. W., Jaing, T. H., ... Lin, J. C. (2003). Childhood Langerhans cell histiocytosis increased during El Niño 1997-98: A report from the Taiwan Pediatric Oncology Group. Acta Paediatrica Taiwanica, 44(1), 14-20.

Childhood Langerhans cell histiocytosis increased during El Niño 1997-98 : A report from the Taiwan Pediatric Oncology Group. / Chen, Rong Long; Lin, Kuo Sin; Chang, Wan Hui; Hsieh, Yuh Lin; Chen, Bow Wen; Jaing, Tang Her; Yang, Chao Ping; Hung, Iou Jih; Peng, Ching Tien; Shu, San Ging; Lu, Meng Yao; Jou, Sheng Tang; Lin, Kai Hsin; Lin, Dong Tsamn; Lin, Ming Tsan; Chen, Jiann Shiuh; Liu, His Che; Chen, Shu Huey; Liang, Der Cherng; Chiou, Shyh Shin; Chang, Tai Tsung; Sheen, Jiunn Ming; Hsiao, Chih Cheng; Cheng, Shin Nan; Lin, Jung Chung.

In: Acta Paediatrica Taiwanica, Vol. 44, No. 1, 01.2003, p. 14-20.

Research output: Contribution to journalArticle

Chen, RL, Lin, KS, Chang, WH, Hsieh, YL, Chen, BW, Jaing, TH, Yang, CP, Hung, IJ, Peng, CT, Shu, SG, Lu, MY, Jou, ST, Lin, KH, Lin, DT, Lin, MT, Chen, JS, Liu, HC, Chen, SH, Liang, DC, Chiou, SS, Chang, TT, Sheen, JM, Hsiao, CC, Cheng, SN & Lin, JC 2003, 'Childhood Langerhans cell histiocytosis increased during El Niño 1997-98: A report from the Taiwan Pediatric Oncology Group', Acta Paediatrica Taiwanica, vol. 44, no. 1, pp. 14-20.
Chen, Rong Long ; Lin, Kuo Sin ; Chang, Wan Hui ; Hsieh, Yuh Lin ; Chen, Bow Wen ; Jaing, Tang Her ; Yang, Chao Ping ; Hung, Iou Jih ; Peng, Ching Tien ; Shu, San Ging ; Lu, Meng Yao ; Jou, Sheng Tang ; Lin, Kai Hsin ; Lin, Dong Tsamn ; Lin, Ming Tsan ; Chen, Jiann Shiuh ; Liu, His Che ; Chen, Shu Huey ; Liang, Der Cherng ; Chiou, Shyh Shin ; Chang, Tai Tsung ; Sheen, Jiunn Ming ; Hsiao, Chih Cheng ; Cheng, Shin Nan ; Lin, Jung Chung. / Childhood Langerhans cell histiocytosis increased during El Niño 1997-98 : A report from the Taiwan Pediatric Oncology Group. In: Acta Paediatrica Taiwanica. 2003 ; Vol. 44, No. 1. pp. 14-20.
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AU - Jaing, Tang Her

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AU - Shu, San Ging

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AU - Jou, Sheng Tang

AU - Lin, Kai Hsin

AU - Lin, Dong Tsamn

AU - Lin, Ming Tsan

AU - Chen, Jiann Shiuh

AU - Liu, His Che

AU - Chen, Shu Huey

AU - Liang, Der Cherng

AU - Chiou, Shyh Shin

AU - Chang, Tai Tsung

AU - Sheen, Jiunn Ming

AU - Hsiao, Chih Cheng

AU - Cheng, Shin Nan

AU - Lin, Jung Chung

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