Chemotherapy of the blastic phase of chronic granulocytic leukemia

hypodiploidy and response to therapy

G. P. Canellos, V. T. DeVita, J. Whang-Peng, B. A. Chabner, P. S. Schein, R. C. Young

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Thirty two patients in the blastic phase of Philadelphia chromosome positive chronic granulocytic leukemia (CGL) were studied in a prospective randomized trial in which vincristine prednisone (19 patients) was compared with cytosine arabinoside 6 thioguanine (13 patients). Seven remissions (37%), including two complete remissions, were achieved in the vincristine prednisone group. Three of the five with predominant hypodiploid blast cell lines treated with vincristine prednisone had complete or partial remissions. Both complete remitters presented with hypodiploidy consisting of 44 chromosomes. Four patients (30%) who were treated with cytosine arabinoside 6 thioguanine responded with one complete remission. The median survival of the responders was 8 mo, as compared to 1-2 mo for the nonresponders. Crossover to the opposite regimen as secondary therapy following refractoriness or resistance resulted in only 3 partial responses out of 21 treated. All three had previously responded to vincristine prednisone. Of the 32 cases, 14 had an elective splenectomy during the chronic phase of the disease. Prior splenectomy did not influence the response to chemotherapy, as all three complete remitters occurred in the nonsplenectomized group. Similarly, survival in the blastic phase was not affected by prior splenectomy.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalBlood
Volume47
Issue number6
Publication statusPublished - Dec 1 1976
Externally publishedYes

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Leukemia, Myeloid, Chronic Phase
Chemotherapy
Vincristine
Prednisone
Splenectomy
Thioguanine
Drug Therapy
Cytarabine
Chromosomes
Philadelphia Chromosome
Survival
Therapeutics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chronic Disease
Cells
Cell Line

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Canellos, G. P., DeVita, V. T., Whang-Peng, J., Chabner, B. A., Schein, P. S., & Young, R. C. (1976). Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy. Blood, 47(6), 1003-1009.

Chemotherapy of the blastic phase of chronic granulocytic leukemia : hypodiploidy and response to therapy. / Canellos, G. P.; DeVita, V. T.; Whang-Peng, J.; Chabner, B. A.; Schein, P. S.; Young, R. C.

In: Blood, Vol. 47, No. 6, 01.12.1976, p. 1003-1009.

Research output: Contribution to journalArticle

Canellos, GP, DeVita, VT, Whang-Peng, J, Chabner, BA, Schein, PS & Young, RC 1976, 'Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy', Blood, vol. 47, no. 6, pp. 1003-1009.
Canellos GP, DeVita VT, Whang-Peng J, Chabner BA, Schein PS, Young RC. Chemotherapy of the blastic phase of chronic granulocytic leukemia: hypodiploidy and response to therapy. Blood. 1976 Dec 1;47(6):1003-1009.
Canellos, G. P. ; DeVita, V. T. ; Whang-Peng, J. ; Chabner, B. A. ; Schein, P. S. ; Young, R. C. / Chemotherapy of the blastic phase of chronic granulocytic leukemia : hypodiploidy and response to therapy. In: Blood. 1976 ; Vol. 47, No. 6. pp. 1003-1009.
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