Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy

Rong Jane Chen, Shang Jie Tsai, Chi Tang Ho, Min Hsiung Pan, Yuan-Soon Ho, Chih-Hsiung Wu, Ying Jan Wang

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer deaths globally. Due to the lack of successful chemopreventive agents for lung cancer, there is an emerging need to evaluate new and effective agents for lung cancer prevention. Pterostilbene, a naturally occurring analogue of resveratrol, has been reported to be an effective chemopreventive agent against many cancers. The aim of this study is to investigate the chemopreventive effects of pterostilbene in urethane-induced murine lung tumors. Pretreatment with pterostilbene at 50 or 250 mg/kg significantly reduced tumor multiplicity by 26 and 49%, respectively. Pterostilbene also significantly inhibited tumor volume by 25 and 34% and decreased the tumor burden per mouse by 45 and 63%, respectively. The mechanisms by which pterostilbene suppresses lung tumorigenesis have been investigated in lung tissues and homogenates. The results indicate that the pterostilbene-mediated chemopreventive effects in vivo were a result of the inhibition of epidermal growth factor receptor (EGFR) and its downstream pathways, leading to retarded cell cycle progression, and of the induction of apoptosis and autophagy during urethane-induced lung tumorigenesis.

Original languageEnglish
Pages (from-to)11533-11541
Number of pages9
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number46
DOIs
Publication statusPublished - Nov 21 2012

Fingerprint

urethane
autophagy
Urethane
Autophagy
Epidermal Growth Factor Receptor
carcinogenesis
Carcinogenesis
apoptosis
lungs
lung neoplasms
Apoptosis
Lung
neoplasms
Tumors
mice
Lung Neoplasms
Neoplasms
Tumor Burden
resveratrol
pterostilbene

Keywords

  • autophagy
  • chemopreventive
  • EGFR
  • pterostilbene
  • urethane

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

Cite this

Chemopreventive effects of pterostilbene on urethane-induced lung carcinogenesis in mice via the inhibition of EGFR-mediated pathways and the induction of apoptosis and autophagy. / Chen, Rong Jane; Tsai, Shang Jie; Ho, Chi Tang; Pan, Min Hsiung; Ho, Yuan-Soon; Wu, Chih-Hsiung; Wang, Ying Jan.

In: Journal of Agricultural and Food Chemistry, Vol. 60, No. 46, 21.11.2012, p. 11533-11541.

Research output: Contribution to journalArticle

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