Chemical Constituents of the Endophytic Fungus Phomopsis asparagi Isolated from the Plant Peperomia sui

Hsun Shuo Chang, Chien Jou Peng, Ming Jen Cheng, Ho Cheng Wu, Hing Yuen Chan, Sung Yuan Hsieh, Gwo Fang Yuan, Ih Sheng Chen

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Investigation of the ethyl acetate-soluble layer from the liquid fermentation of Phomopsis asparagi, an endophytic fungus isolated from the Taiwanese endemic plant of Peperomia sui T.T. Lin & S.Y. Lu, led to the isolation of a new cytochalasin, phomocytochalasin A (1), and one benzenoid, phomoaspardiol (2), which was isolated from nature for the first time, along with eight known compounds including two cytochalasins, four benzenoids, one chromone, and one steroid. The structures of the isolates were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D and 2D NMR techniques, as well as by comparison with literature reports. Among the isolates, cytochalasin J showed androgen receptor (AR) antagonism with the IC50 value of 6.20 μM.

Original languageEnglish
Pages (from-to)504-508
Number of pages5
JournalChemistry of Natural Compounds
Volume54
Issue number3
DOIs
Publication statusPublished - May 1 2018
Externally publishedYes

Keywords

  • androgen antagonism
  • benzenoid
  • cytochalasin
  • Peperomia sui
  • Phomopsis asparagi

ASJC Scopus subject areas

  • Plant Science

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