Chemical constituents from the fungus antrodia cinnamomea

Ming Der Wu; Ming Jen Cheng; Yen Lin Chen; Hsun-Hsuo-Chang; Yueh Hsiung Kuo; Chih Chuan Lin; Ho Cheng Wu

doi:10.1177/1934578X1901400134

Chemical constituents from the fungus antrodia cinnamomea

Ming Der Wu, Ming Jen Cheng, Yen Lin Chen, Hsun-Hsuo-Chang, Yueh Hsiung Kuo, Chih Chuan Lin, Ho Cheng Wu

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2- methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 μM in vitro.

Original language	English
Pages (from-to)	129-130
Number of pages	2
Journal	Natural Product Communications
Volume	14
Issue number	1
DOIs	https://doi.org/10.1177/1934578X1901400134
Publication status	Published - Jan 2019
Externally published	Yes

Keywords

Antrodia cinnamomea
Benzenoid
Cytotoxicity
Polyporaceae

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Plant Science
Complementary and alternative medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1934578X1901400134

Cite this

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title = "Chemical constituents from the fungus antrodia cinnamomea",

abstract = "A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2- methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 μM in vitro.",

keywords = "Antrodia cinnamomea, Benzenoid, Cytotoxicity, Polyporaceae",

author = "Wu, {Ming Der} and Cheng, {Ming Jen} and Chen, {Yen Lin} and Hsun-Hsuo-Chang and Kuo, {Yueh Hsiung} and Lin, {Chih Chuan} and Wu, {Ho Cheng}",

year = "2019",

month = jan,

doi = "10.1177/1934578X1901400134",

language = "English",

volume = "14",

pages = "129--130",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "Natural Product Communications",

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T1 - Chemical constituents from the fungus antrodia cinnamomea

AU - Wu, Ming Der

AU - Cheng, Ming Jen

AU - Chen, Yen Lin

AU - Hsun-Hsuo-Chang,

AU - Kuo, Yueh Hsiung

AU - Lin, Chih Chuan

AU - Wu, Ho Cheng

PY - 2019/1

Y1 - 2019/1

N2 - A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2- methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 μM in vitro.

AB - A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2- methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 μM in vitro.

KW - Antrodia cinnamomea

KW - Benzenoid

KW - Cytotoxicity

KW - Polyporaceae

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U2 - 10.1177/1934578X1901400134

DO - 10.1177/1934578X1901400134

M3 - Article

AN - SCOPUS:85063739406

VL - 14

SP - 129

EP - 130

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

IS - 1

ER -

Chemical constituents from the fungus antrodia cinnamomea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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