Chemical constituents from the fungus antrodia cinnamomea

Ming Der Wu, Ming Jen Cheng, Yen Lin Chen, Hsun-Hsuo-Chang, Yueh Hsiung Kuo, Chih Chuan Lin, Ho Cheng Wu

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A new benzenoid, 4-methoxy-7-methylbenzo[d][1,3]dioxol-5-ol (1) and three known secondary metabolites 2,3-dimethoxy-5-methyl[1,4]benzoquinone (2), 2- methoxy-6-methyl-1,4-benzoquinone (3) and 5-methyl-benzo[1,3]dioxole-4,7-diol (4) were isolated from the mycelia of A. cinnamomea BCRC 36799 by solid state fermentation with adlay. Their chemical structures were elucidated on the basis of HRESIMS, NMR spectroscopic data and comparison with reported values. All isolated compounds 1-4 were tested for their cytotoxicity against the six cancer cell lines using the MTT assay. Among them, compound 3 displayed significant cytotoxic effects toward all six tested cancer cell lines, with IC50 values ranging from 2.8-8.7 μM in vitro.

Original languageEnglish
Pages (from-to)129-130
Number of pages2
JournalNatural Product Communications
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2019
Externally publishedYes

Keywords

  • Antrodia cinnamomea
  • Benzenoid
  • Cytotoxicity
  • Polyporaceae

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Fingerprint

Dive into the research topics of 'Chemical constituents from the fungus antrodia cinnamomea'. Together they form a unique fingerprint.

Cite this