Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan

Chen Yu Chen, Fu Yu Chiu, Yenshou Lin, Wei Jan Huang, Po Shiuan Hsieh, Feng-Lin Hsu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Pterosins are abundant in ferns, and pterosin A was considered a novel activator of adenosine monophosphate-activated protein kinase, which is crucial for regulating blood glucose homeostasis. However, the distribution of pterosins in different species of ferns from various places in Taiwan is currently unclear. To address this question, the distribution of pterosins, glucose-uptake efficiency, and protective effects of pterosin A on β-cells were examined. Our results showed that three novel compounds, 13-chloro-spelosin 3-O-β-D-glucopyranoside (1), (3R)-Pterosin D 3-O-β-D-(3'-p-coumaroyl)-glucopyranoside (2), and (2R,3R)-Pterosin L 3-O-β-D-(3'-p-coumaroyl)-glucopyranoside (3), were isolated for the first time from four fern species (Ceratopteris thalictroides, Hypolepis punctata, Nephrolepis multiflora, and Pteridium revolutum) along with 27 known compounds. We also examined the distribution of these pterosin compounds in the mentioned fern species (except N. multiflora). Although all pterosin analogs exhibited the same effects in glucose uptake assays, pterosin A prevented cell death and reduced reactive oxygen species (ROS) production. This paper is the first report to provide new insights into the distribution of pterosins in ferns from Taiwan. The potential anti-diabetic activity of these novel phytocompounds warrants further functional studies.

Original languageEnglish
Pages (from-to)2497-2516
Number of pages20
JournalInternational Journal of Molecular Sciences
Volume16
Issue number2
DOIs
Publication statusPublished - Jan 22 2015

Fingerprint

Ferns
Taiwan
chemical analysis
Hypoglycemic Agents
Glucose
glucose
Chemical analysis
Cell death
adenosine monophosphate
homeostasis
Assays
Blood
death
blood
Proteins
Oxygen
Pteridium
analogs
proteins
pterosin

Keywords

  • Pterosin
  • Rat pancreatic insulin-secreting (RINm5F) cells
  • Reactive oxygen species (ROS)

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications

Cite this

Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. / Chen, Chen Yu; Chiu, Fu Yu; Lin, Yenshou; Huang, Wei Jan; Hsieh, Po Shiuan; Hsu, Feng-Lin.

In: International Journal of Molecular Sciences, Vol. 16, No. 2, 22.01.2015, p. 2497-2516.

Research output: Contribution to journalArticle

Chen, Chen Yu ; Chiu, Fu Yu ; Lin, Yenshou ; Huang, Wei Jan ; Hsieh, Po Shiuan ; Hsu, Feng-Lin. / Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. In: International Journal of Molecular Sciences. 2015 ; Vol. 16, No. 2. pp. 2497-2516.
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