Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of Actinidia callosa var. ephippioides

Jung Chun Liao, Jeng Shyan Deng, Chuan Sung Chiu, Shyh Shyun Huang, Wen Chi Hou, Wang Ching Lin, Guan Jhong Huang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Oxidative stress and inflammation are related to several chronic diseases including cancer. Actinidia callosa var. ephippioides (ACE) is a special folk medicinal plant from Taiwan. The aim of this study is to evaluate the antioxidant, anti-inflammatory, and antiproliferative activities of the methanol extract and fractions from the stem of ACE. Trolox Equivalent Antioxidant Capacity (TEAC), 1,1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, total phenolic content, flavonoid content, inhibition on nitric oxide (NO) productions by LPS-induced RAW264.7 cell, and on lung cancer cell proliferation were employed. Among all fractions, ethyl-acetate fraction (EA-ACE) showed higher TEAC, DPPH radical scavenging activities, polyphenol and flavonoid contents, respectively. EA-ACE also decreased the LPS-induced NO production and expressions of inducible nitric-oxide synthase (iNOS) in RAW264.7 cells. EA-ACE had the highest antiproliferative activity with an IC50 (The concentrations required for inhibition of 50% of cell viability) of 469.17 ± 3.59 μg/mL. Catechin also had good effects in the antioxidant and anti-inflammatory activities. Catechin might be an important bioactive compound in the stem of ACE. The above experimental data indicated that the stem of ACE is a potent antioxidant medicinal plant, and such efficacy may be mainly attributed to its polyphenolic compounds.

Original languageEnglish
Pages (from-to)1047-1062
Number of pages16
JournalAmerican Journal of Chinese Medicine
Volume40
Issue number5
DOIs
Publication statusPublished - 2012

Fingerprint

Actinidia
Anti-Inflammatory Agents
Antioxidants
Catechin
Medicinal Plants
Flavonoids
Nitric Oxide
Polyphenols
Nitric Oxide Synthase Type II
Taiwan
Inhibitory Concentration 50
Methanol
Lung Neoplasms
Cell Survival
Oxidative Stress
Chronic Disease
Cell Proliferation
Inflammation
Neoplasms

Keywords

  • Actinidia callosa var. ephippioides
  • Anti-Inflammatory Activity
  • Antioxidant Activity
  • Antiproliferation

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of Actinidia callosa var. ephippioides. / Liao, Jung Chun; Deng, Jeng Shyan; Chiu, Chuan Sung; Huang, Shyh Shyun; Hou, Wen Chi; Lin, Wang Ching; Huang, Guan Jhong.

In: American Journal of Chinese Medicine, Vol. 40, No. 5, 2012, p. 1047-1062.

Research output: Contribution to journalArticle

Liao, Jung Chun ; Deng, Jeng Shyan ; Chiu, Chuan Sung ; Huang, Shyh Shyun ; Hou, Wen Chi ; Lin, Wang Ching ; Huang, Guan Jhong. / Chemical compositions, anti-inflammatory, antiproliferative and radical-scavenging activities of Actinidia callosa var. ephippioides. In: American Journal of Chinese Medicine. 2012 ; Vol. 40, No. 5. pp. 1047-1062.
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