ChemDIS 2: An update of chemical-disease inference system

Chun Wei Tung, Shan Shan Wang

Research output: Contribution to journalArticle

Abstract

Computational inference of affected functions, pathways and diseases for chemicals could largely accelerate the evaluation of potential effects of chemical exposure on human beings. Previously, we have developed a ChemDIS system utilizing information of interacting targets for chemical-disease inference. With the target information, testable hypotheses can be generated for experimental validation. In this work, we present an update of ChemDIS 2 system featured with more updated datasets and several new functions, including (i) custom enrichment analysis function for single omics data; (ii) multi-omics analysis function for joint analysis of multi-omics data; (iii) mixture analysis function for the identification of interaction and overall effects; (iv) web application programming interface (API) for programmed access to ChemDIS 2. The updated ChemDIS 2 system capable of analyzing more than 430 000 chemicals is expected to be useful for both drug development and risk assessment of environmental chemicals.

Original languageEnglish
JournalDatabase
Volume2018
Issue number2018
DOIs
Publication statusPublished - Jan 1 2018
Externally publishedYes

Fingerprint

environmental assessment
Information Systems
drugs
Pharmaceutical Preparations
Application programming interfaces (API)
Risk assessment
Information systems
Datasets

ASJC Scopus subject areas

  • Information Systems
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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ChemDIS 2 : An update of chemical-disease inference system. / Tung, Chun Wei; Wang, Shan Shan.

In: Database, Vol. 2018, No. 2018, 01.01.2018.

Research output: Contribution to journalArticle

Tung, Chun Wei ; Wang, Shan Shan. / ChemDIS 2 : An update of chemical-disease inference system. In: Database. 2018 ; Vol. 2018, No. 2018.
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