Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato paste

Yuan Man Hsu, Ching Hsiu Lai, Chih Yue Chang, Chien Teng Fan, Ching Tan Chen, Chieh Hsi Wu

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Lycopene is known to decrease cardiovascular risks. The objective of this study was to investigate the molecular mechanisms of tomato paste containing approximately 0.1% lycopene in regulating lipid metabolism and oxidation. Hamsters fed 3% or 9% tomato paste containing 0.2% cholesterol were subjected to total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein (HDL), and triglyceride (TG) measurements. Our results showed reduced rates of serum TC and LDL levels due to 9% tomato paste were 14.3% and 11.3% respectively. Concentrations of 3% and 9% of tomato paste after 8 weeks of feeding significantly increased serum HDL levels, by 19.4% and 28.8% respectively. After ingestion of tomato paste for 8 weeks, the plasma malondialdehyde (MDA) levels significantly decreased, by 80.18% and 89.33% respectively, as compared to the cholesterol group. MDA and diene conjugation assays indicated the potent antioxidant activity of the tomato paste. The increased activities of superoxide dismutases (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px), further supported the antioxidant effects of the tomato paste. Two dimension-gel electrophoresis (2-DE) analysis revealed that carbonic anhydrase III (CAIII) and adenylate kinase 2 (AK2) may be two important regulators involved in the anti-lipid and antioxidant effects of tomato paste, opening new insight into the nutritional value of tomato in public health promotion.

Original languageEnglish
Pages (from-to)677-685
Number of pages9
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number3
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

lipemic effect
tomato paste
Lipoproteins
Cholesterol
Lycopersicon esculentum
Ointments
Antioxidants
Lipids
antioxidants
Carbonic anhydrase
high density lipoprotein
cholesterol
Public health
HDL Lipoproteins
lycopene
Electrophoresis
Malondialdehyde
glutathione peroxidase
LDL Cholesterol
malondialdehyde

Keywords

  • Atherogenesis
  • Cholesterol
  • Oxidation
  • Tomato paste

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato paste. / Hsu, Yuan Man; Lai, Ching Hsiu; Chang, Chih Yue; Fan, Chien Teng; Chen, Ching Tan; Wu, Chieh Hsi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 3, 2008, p. 677-685.

Research output: Contribution to journalArticle

Hsu, Yuan Man ; Lai, Ching Hsiu ; Chang, Chih Yue ; Fan, Chien Teng ; Chen, Ching Tan ; Wu, Chieh Hsi. / Characterizing the lipid-lowering effects and antioxidant mechanisms of tomato paste. In: Bioscience, Biotechnology and Biochemistry. 2008 ; Vol. 72, No. 3. pp. 677-685.
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