TY - JOUR
T1 - Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy
AU - Hardiansyah, Andri
AU - Destyorini, Fredina
AU - Irmawati, Yuyun
AU - Yang, Ming Chien
AU - Liu, Chi Ming
AU - Chaldun, Elsy Rahimi
AU - Yung, Ming Chi
AU - Liu, Ting Yu
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.
AB - Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.
KW - Cytocompatibility
KW - Doxorubicin
KW - Liposomes
KW - Magnetic nanoparticles
KW - Poly-(ethylene glycol)
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UR - http://www.scopus.com/inward/citedby.url?scp=85075498535&partnerID=8YFLogxK
U2 - 10.1007/s10965-019-1964-5
DO - 10.1007/s10965-019-1964-5
M3 - Article
AN - SCOPUS:85075498535
VL - 26
JO - Journal of Polymer Research
JF - Journal of Polymer Research
SN - 1022-9760
IS - 12
M1 - 282
ER -
