Characterizations of doxorubicin-loaded PEGylated magnetic liposomes for cancer cells therapy

Andri Hardiansyah, Fredina Destyorini, Yuyun Irmawati, Ming Chien Yang, Chi Ming Liu, Elsy Rahimi Chaldun, Ming Chi Yung, Ting Yu Liu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Magnetic-guided drug delivery system for cancer treatment can be realized by elaborating drug and magnetic nanoparticles (MNP) on the liposomes through the assistance of magnetic field exposure. Here, we prepared PEGylated liposomes (liposomes with poly-(ethylene glycol) (PEG) modification) to encapsulate doxorubicin (DOX) and MNP, termed as DOX-loaded PEGylated magnetic liposomes. We show that the DOX-loaded PEGylated magnetic liposomes exhibits spherical morphology with diameter about 100 nm, dispersed homogeneously in aqueous system and generate inductive heating from 37o to 56 °C by means of high-frequency magnetic field (HFMF) exposure. Moreover, DOX could kill HeLa cells due to DOX releasing indicating the DOX cytotoxicity to the HeLa cells as a function of DOX concentration. In conclusion, these liposomes could combine the function of DOX and MNP, opening a route as a drug carrier platform to enhance the therapeutic efficacy of chemotherapeutic drug and it could be integrated with the development of magnetic-guided drug delivery.

Original languageEnglish
Article number282
JournalJournal of Polymer Research
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 1 2019

Keywords

  • Cytocompatibility
  • Doxorubicin
  • Liposomes
  • Magnetic nanoparticles
  • Poly-(ethylene glycol)

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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