Abstract
A chitosan-based polymeric network was synthesized by crosslinking with a naturally occurring crosslinking agent, genipin. The result showed that the crosslinking reactions were pH-dependent. Under basic conditions, genipin underwent a ring-opening polymerization prior to crosslinking with chitosan. This ring-opening polymerization of geninpin was initiated by extracting proton from the hydroxyl groups at C-1 deoxylaganin aglycone, followed by opening the dihydropyran ring to conduct an aldol condensation. The results indicated a direct relationship between the mode of crosslinking reaction, and the swelling and enzymatic hydrolysis properties of the genipin-crosslinking chitosan gels.
| Original language | English |
|---|---|
| Pages (from-to) | 1985-2000 |
| Number of pages | 16 |
| Journal | Journal of Polymer Science, Part A: Polymer Chemistry |
| Volume | 43 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - May 15 2005 |
| Externally published | Yes |
Keywords
- Chitosan
- Crosslinking
- Genipin
- Network
- Ring-opening polymerization
ASJC Scopus subject areas
- Materials Chemistry
- Polymers and Plastics
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Mi, F. L., Shyu, S. S., & Peng, C. K. (2005). Characterization of ring-opening polymerization of genipin and pH-dependent cross-linking reactions between chitosan and genipin. Journal of Polymer Science, Part A: Polymer Chemistry, 43(10), 1985-2000. https://doi.org/10.1002/pola.20669