Characterization of neuroblastic tumors using 18F-FDOPA PET

Meng Yao Lu, Yen Lin Liu, Hsiu Hao Chang, Shiann Tarng Jou, Yung Li Yang, Kai Hsin Lin, Dong Tsamn Lin, Ya Ling Lee, Hsinyu Lee, Pei Yi Wu, Tsai Yueh Luo, Lie Hang Shen, Shiu Feng Huang, Yung Feng Liao, Wen Ming Hsu, Kai Yuan Tzen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of 18F-FDOPA PET in neuroblastic tumors. Methods: From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving 18F-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of 18F-FDOPA PET were compared with those of 123I-metaiodobenzylguanidine ( 123I-MIBG) scintigraphy and 18F-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on 18F-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Results: Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. 18F-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6% (87.4%- 99.9%) and a specificity of 87.5% (47.3%-99.7%). In tumors with concomitant studies, 18F-FDOPA PET demonstrated a higher sensitivity than 123I-MIBG scintigraphy (n = 18; P = 0.0455) or 18F-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant 123I- MIBG scans, 4 tumors with viable cells were 123I-MIBG-negative but were successfully detected by 18F-FDOPA PET. The tumor uptake of 18F-FDOPA significantly correlated with AADC expression (n 5 15 nonhepatic tumors; maximum standardized uptake value, P 5 0.0002; tumor-to-liver uptake ratio, P < 0.0001). Conclusion: 18F- FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to 123I-MIBG scintigraphy and 18F-FDG PET. By correlating with AADC expression, 18F-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. COPYRIGHT

Original languageEnglish
Pages (from-to)42-49
Number of pages8
JournalJournal of Nuclear Medicine
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Neoplasms
Carboxy-Lyases
Fluorodeoxyglucose F18
Radionuclide Imaging
Amino Acids
3-Iodobenzylguanidine
Sensitivity and Specificity
Neuroendocrine Tumors
Liver
Histology
Messenger RNA

Keywords

  • F-FDOPA
  • Ganglioneuroma
  • Neuroblastoma
  • Positron emission tomography
  • Sensitivity and specificity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Lu, M. Y., Liu, Y. L., Chang, H. H., Jou, S. T., Yang, Y. L., Lin, K. H., ... Tzen, K. Y. (2013). Characterization of neuroblastic tumors using 18F-FDOPA PET. Journal of Nuclear Medicine, 54(1), 42-49. https://doi.org/10.2967/jnumed.112.102772

Characterization of neuroblastic tumors using 18F-FDOPA PET. / Lu, Meng Yao; Liu, Yen Lin; Chang, Hsiu Hao; Jou, Shiann Tarng; Yang, Yung Li; Lin, Kai Hsin; Lin, Dong Tsamn; Lee, Ya Ling; Lee, Hsinyu; Wu, Pei Yi; Luo, Tsai Yueh; Shen, Lie Hang; Huang, Shiu Feng; Liao, Yung Feng; Hsu, Wen Ming; Tzen, Kai Yuan.

In: Journal of Nuclear Medicine, Vol. 54, No. 1, 01.2013, p. 42-49.

Research output: Contribution to journalArticle

Lu, MY, Liu, YL, Chang, HH, Jou, ST, Yang, YL, Lin, KH, Lin, DT, Lee, YL, Lee, H, Wu, PY, Luo, TY, Shen, LH, Huang, SF, Liao, YF, Hsu, WM & Tzen, KY 2013, 'Characterization of neuroblastic tumors using 18F-FDOPA PET', Journal of Nuclear Medicine, vol. 54, no. 1, pp. 42-49. https://doi.org/10.2967/jnumed.112.102772
Lu, Meng Yao ; Liu, Yen Lin ; Chang, Hsiu Hao ; Jou, Shiann Tarng ; Yang, Yung Li ; Lin, Kai Hsin ; Lin, Dong Tsamn ; Lee, Ya Ling ; Lee, Hsinyu ; Wu, Pei Yi ; Luo, Tsai Yueh ; Shen, Lie Hang ; Huang, Shiu Feng ; Liao, Yung Feng ; Hsu, Wen Ming ; Tzen, Kai Yuan. / Characterization of neuroblastic tumors using 18F-FDOPA PET. In: Journal of Nuclear Medicine. 2013 ; Vol. 54, No. 1. pp. 42-49.
@article{3e716f39d2c34989a27eec14dd343aa6,
title = "Characterization of neuroblastic tumors using 18F-FDOPA PET",
abstract = "Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of 18F-FDOPA PET in neuroblastic tumors. Methods: From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving 18F-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of 18F-FDOPA PET were compared with those of 123I-metaiodobenzylguanidine ( 123I-MIBG) scintigraphy and 18F-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on 18F-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Results: Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. 18F-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6{\%} (87.4{\%}- 99.9{\%}) and a specificity of 87.5{\%} (47.3{\%}-99.7{\%}). In tumors with concomitant studies, 18F-FDOPA PET demonstrated a higher sensitivity than 123I-MIBG scintigraphy (n = 18; P = 0.0455) or 18F-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant 123I- MIBG scans, 4 tumors with viable cells were 123I-MIBG-negative but were successfully detected by 18F-FDOPA PET. The tumor uptake of 18F-FDOPA significantly correlated with AADC expression (n 5 15 nonhepatic tumors; maximum standardized uptake value, P 5 0.0002; tumor-to-liver uptake ratio, P < 0.0001). Conclusion: 18F- FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to 123I-MIBG scintigraphy and 18F-FDG PET. By correlating with AADC expression, 18F-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. COPYRIGHT",
keywords = "F-FDOPA, Ganglioneuroma, Neuroblastoma, Positron emission tomography, Sensitivity and specificity",
author = "Lu, {Meng Yao} and Liu, {Yen Lin} and Chang, {Hsiu Hao} and Jou, {Shiann Tarng} and Yang, {Yung Li} and Lin, {Kai Hsin} and Lin, {Dong Tsamn} and Lee, {Ya Ling} and Hsinyu Lee and Wu, {Pei Yi} and Luo, {Tsai Yueh} and Shen, {Lie Hang} and Huang, {Shiu Feng} and Liao, {Yung Feng} and Hsu, {Wen Ming} and Tzen, {Kai Yuan}",
year = "2013",
month = "1",
doi = "10.2967/jnumed.112.102772",
language = "English",
volume = "54",
pages = "42--49",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "1",

}

TY - JOUR

T1 - Characterization of neuroblastic tumors using 18F-FDOPA PET

AU - Lu, Meng Yao

AU - Liu, Yen Lin

AU - Chang, Hsiu Hao

AU - Jou, Shiann Tarng

AU - Yang, Yung Li

AU - Lin, Kai Hsin

AU - Lin, Dong Tsamn

AU - Lee, Ya Ling

AU - Lee, Hsinyu

AU - Wu, Pei Yi

AU - Luo, Tsai Yueh

AU - Shen, Lie Hang

AU - Huang, Shiu Feng

AU - Liao, Yung Feng

AU - Hsu, Wen Ming

AU - Tzen, Kai Yuan

PY - 2013/1

Y1 - 2013/1

N2 - Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of 18F-FDOPA PET in neuroblastic tumors. Methods: From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving 18F-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of 18F-FDOPA PET were compared with those of 123I-metaiodobenzylguanidine ( 123I-MIBG) scintigraphy and 18F-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on 18F-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Results: Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. 18F-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6% (87.4%- 99.9%) and a specificity of 87.5% (47.3%-99.7%). In tumors with concomitant studies, 18F-FDOPA PET demonstrated a higher sensitivity than 123I-MIBG scintigraphy (n = 18; P = 0.0455) or 18F-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant 123I- MIBG scans, 4 tumors with viable cells were 123I-MIBG-negative but were successfully detected by 18F-FDOPA PET. The tumor uptake of 18F-FDOPA significantly correlated with AADC expression (n 5 15 nonhepatic tumors; maximum standardized uptake value, P 5 0.0002; tumor-to-liver uptake ratio, P < 0.0001). Conclusion: 18F- FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to 123I-MIBG scintigraphy and 18F-FDG PET. By correlating with AADC expression, 18F-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. COPYRIGHT

AB - Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of 18F-FDOPA PET in neuroblastic tumors. Methods: From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving 18F-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of 18F-FDOPA PET were compared with those of 123I-metaiodobenzylguanidine ( 123I-MIBG) scintigraphy and 18F-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on 18F-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Results: Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. 18F-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6% (87.4%- 99.9%) and a specificity of 87.5% (47.3%-99.7%). In tumors with concomitant studies, 18F-FDOPA PET demonstrated a higher sensitivity than 123I-MIBG scintigraphy (n = 18; P = 0.0455) or 18F-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant 123I- MIBG scans, 4 tumors with viable cells were 123I-MIBG-negative but were successfully detected by 18F-FDOPA PET. The tumor uptake of 18F-FDOPA significantly correlated with AADC expression (n 5 15 nonhepatic tumors; maximum standardized uptake value, P 5 0.0002; tumor-to-liver uptake ratio, P < 0.0001). Conclusion: 18F- FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to 123I-MIBG scintigraphy and 18F-FDG PET. By correlating with AADC expression, 18F-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. COPYRIGHT

KW - F-FDOPA

KW - Ganglioneuroma

KW - Neuroblastoma

KW - Positron emission tomography

KW - Sensitivity and specificity

UR - http://www.scopus.com/inward/record.url?scp=84872046559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872046559&partnerID=8YFLogxK

U2 - 10.2967/jnumed.112.102772

DO - 10.2967/jnumed.112.102772

M3 - Article

VL - 54

SP - 42

EP - 49

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 1

ER -