Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan

Chung Yu Chang, Yu Ti Fang, Shih Meng Tsai, Lin Li Chang, Wen Liang Yu

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume65
Issue number2
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Class 1 integrons
  • Gene cassettes
  • Klebsiella pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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