Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan

Chung Yu Chang, Yu Ti Fang, Shih Meng Tsai, Lin Li Chang, Wen Liang Yu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalDiagnostic Microbiology and Infectious Disease
Volume65
Issue number2
DOIs
Publication statusPublished - Oct 2009

Fingerprint

Integrons
Klebsiella pneumoniae
Taiwan
Genes

Keywords

  • Class 1 integrons
  • Gene cassettes
  • Klebsiella pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan. / Chang, Chung Yu; Fang, Yu Ti; Tsai, Shih Meng; Chang, Lin Li; Yu, Wen Liang.

In: Diagnostic Microbiology and Infectious Disease, Vol. 65, No. 2, 10.2009, p. 214-216.

Research output: Contribution to journalArticle

@article{3069c88e36a24f32b2571f67291e140e,
title = "Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan",
abstract = "We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2{\%}) from 1993 (n = 228) and 129 (32.9{\%}) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.",
keywords = "Class 1 integrons, Gene cassettes, Klebsiella pneumoniae",
author = "Chang, {Chung Yu} and Fang, {Yu Ti} and Tsai, {Shih Meng} and Chang, {Lin Li} and Yu, {Wen Liang}",
year = "2009",
month = "10",
doi = "10.1016/j.diagmicrobio.2009.06.005",
language = "English",
volume = "65",
pages = "214--216",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Characterization of class 1 integrons and gene cassettes in clinical isolates of Klebsiella pneumoniae from Taiwan

AU - Chang, Chung Yu

AU - Fang, Yu Ti

AU - Tsai, Shih Meng

AU - Chang, Lin Li

AU - Yu, Wen Liang

PY - 2009/10

Y1 - 2009/10

N2 - We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

AB - We surveyed the prevalence and contents of class 1 integrons in clinical Klebsiella pneumoniae isolates collected from Kaohsiung, Taiwan, during 2 periods (1993 and 2004). Class 1 integrons were present in 78 isolates (34.2%) from 1993 (n = 228) and 129 (32.9%) from 2004 (n = 392) and contained varied gene cassette number, type, and array. We found 2 atypical sul3-associated class 1 integrons and identified 26 different gene cassettes, including an aac(6′)-Ib-cr cassette here firstly described in K. pneumoniae from Taiwan. The continuing evolution of class 1 integrons is threatening to undermine the effectiveness of antimicrobial therapy for K. pneumoniae.

KW - Class 1 integrons

KW - Gene cassettes

KW - Klebsiella pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=69949092725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69949092725&partnerID=8YFLogxK

U2 - 10.1016/j.diagmicrobio.2009.06.005

DO - 10.1016/j.diagmicrobio.2009.06.005

M3 - Article

C2 - 19748438

AN - SCOPUS:69949092725

VL - 65

SP - 214

EP - 216

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

SN - 0732-8893

IS - 2

ER -