Biocompatibility is the prime requisite for implant material and is determined by the bulk properties and especially the surfaces of implant which directly contacting the host tissue. Even though the relationships and reactions between the surface of implant and tissue and their long-term integrity and clinical efficacy are still not well understood, the first biological reaction known to occur after implantation of a biomaterial is the adsorption of tissue fluid proteins onto its surface and these tightly bound proteins strongly influence the subsequent interactions of cells with the surface. In order to optimize the integration of implants, it is desirable to control interfacial reactions such that nonspecific adsorption of proteins is minimized and beneficial molecules are selectively adsorbed onto biomaterials prior to their implantation. In this regard, our goal was to develop a glow-discharge method to functionalize titanium surfaces by the covalent immobilization of bioactive organic molecules. Based on the above investigation, the surface characteristics was successful modified on the titanium plates by glow discharge technology and this method could offer the possibility of covalently linking selected molecules onto titanium surface in order to guide and promote the tissue healing that occurs during implant integration in bone and soft tissue.
|Original language||Traditional Chinese|
|Number of pages||12|
|Publication status||Published - 2004|
- glow discharge
- cross-linking agent