Characteristics of patients with Clostridium difficile infection in Taiwan

Y. C. Lin, Y. T. Huang, T. F. Lee, N. Y. Lee, C. H. Liao, S. Y. Lin, W. C. Ko, P. R. Hsueh

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The medical records of 84 patients with stool cultures positive for Clostridium difficile during the period August 2007 to June 2009 were retrospectively reviewed. A case of confirmed (toxigenic) C. difficile infection (CDI) was defined by the presence of symptoms (fever, diarrhoea, abdominal discomfort or distension, ileus) and the presence of toxigenic C. difficile. Patients with compatible clinical symptoms and stool cultures positive for non-toxigenic C. difficile isolates were defined as probable (non-toxigenic) CDI cases. Of these 84 patients, 50 (59·5%) were diagnosed as confirmed CDI and 34 (40·5%) as probable CDI. Thirteen (15·5%) of the 84 patients died during their hospital stay. Usage of proton pump inhibitors was a significant independent risk factor for CDI (OR 3·21, P = 0·014). Of the 50 isolates associated with confirmed CDI, seven (8·3%) carried binary toxin genes (cdtAB), and six (7·1%) had a deletion in the tcdC gene. The mortality rate in confirmed CDI patients with isolates exhibiting deletion in the tcdC gene (2/6, 33·3%), those with isolates harbouring binary toxin genes (2/7, 28·6%), and those with isolates containing mutations in gyrA (2/7, 28·6%) and gyrB (1/2, 50%) was higher than the overall mortality rate (10/50, 20%) in patients with confirmed CDI.

Original languageEnglish
Pages (from-to)2031-2038
Number of pages8
JournalEpidemiology and Infection
Volume141
Issue number10
DOIs
Publication statusPublished - Oct 2013

Fingerprint

Clostridium Infections
Clostridium difficile
Taiwan
Genes
Mortality
Ileus
Proton Pump Inhibitors
Medical Records
Diarrhea
Length of Stay
Fever

Keywords

  • clinical characteristics
  • Clostridium difficile infection
  • outcome
  • Taiwan
  • toxin genes

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

Cite this

Lin, Y. C., Huang, Y. T., Lee, T. F., Lee, N. Y., Liao, C. H., Lin, S. Y., ... Hsueh, P. R. (2013). Characteristics of patients with Clostridium difficile infection in Taiwan. Epidemiology and Infection, 141(10), 2031-2038. https://doi.org/10.1017/S0950268812002749

Characteristics of patients with Clostridium difficile infection in Taiwan. / Lin, Y. C.; Huang, Y. T.; Lee, T. F.; Lee, N. Y.; Liao, C. H.; Lin, S. Y.; Ko, W. C.; Hsueh, P. R.

In: Epidemiology and Infection, Vol. 141, No. 10, 10.2013, p. 2031-2038.

Research output: Contribution to journalArticle

Lin, YC, Huang, YT, Lee, TF, Lee, NY, Liao, CH, Lin, SY, Ko, WC & Hsueh, PR 2013, 'Characteristics of patients with Clostridium difficile infection in Taiwan', Epidemiology and Infection, vol. 141, no. 10, pp. 2031-2038. https://doi.org/10.1017/S0950268812002749
Lin, Y. C. ; Huang, Y. T. ; Lee, T. F. ; Lee, N. Y. ; Liao, C. H. ; Lin, S. Y. ; Ko, W. C. ; Hsueh, P. R. / Characteristics of patients with Clostridium difficile infection in Taiwan. In: Epidemiology and Infection. 2013 ; Vol. 141, No. 10. pp. 2031-2038.
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