Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts

Fuu Jen Tsai, Tsung Jung Ho, Chi Fung Cheng, Yi Tzone Shiao, Wen Kuei Chien, Jin Hua Chen, Xiang Liu, Hsinyi Tsang, Ting Hsu Lin, Chiu Chu Liao, Shao Mei Huang, Ju Pi Li, Cheng Wen Lin, Jaung Geng Lin, Yu Ching Lan, Yu Huei Liu, Chien Hui Hung, Jung Chun Lin, Chih Chien Lin, Chih Ho LaiWen Miin Liang, Ying Ju Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Evidence for long-term use of Chinese herbal medicine (CHM) as an adjuvant treatment in patients with type 2 diabetes (T2D) remains limited. This study aimed to assess the frequency of use, utilization patterns, and therapeutic effects of adjuvant CHM for ischemic heart disease (IHD) in patients with T2D in Taiwan. We identified 4620 IHD patients with T2D. After matching for age, gender, and insulin use, 988 subjects each were allocated to a CHM group and a non-CHM group. There were no differences in baseline characteristics except for comorbidities. The CHM group contained more cases with chronic obstructive pulmonary disease, hepatitis, ulcer disease, and hyperlipidemia. The cumulative survival probability was higher in CHM users than in matched non-CHM users aged 60 years or older (P < .0001, log rank test) regardless of gender (P = .0046 for men, P = .0010 for women, log rank test). Among the top 12 CHM combinations, Shu-Jing-Huo-Xue-Tang and Shao-Yao- Gan-Cao-Tang (13.6%) were the most common. This dual combination improved antiapoptotic activity in H2O2-exposed H9C2 cells by enhancing phosphorylation of glycogen synthase kinase-3ß and p38 mitogen-activated protein kinase and could increase the survival of myocardial cells. Our study suggests that adjuvant CHM therapy may increase the survival probability and provides a comprehensive list for future investigations of the safety and efficacy of CHM for IHD patients with T2D.

Original languageEnglish
Pages (from-to)15470-15489
Number of pages20
JournalOncotarget
Volume8
Issue number9
DOIs
Publication statusPublished - 2017

Fingerprint

Herbal Medicine
Type 2 Diabetes Mellitus
Hydrogen Peroxide
Myocardial Ischemia
Apoptosis
Glycyrrhiza uralensis
Phytotherapy
Glycogen Synthase Kinase 3
Survival
Therapeutic Uses
p38 Mitogen-Activated Protein Kinases
Hyperlipidemias
Taiwan
Chronic Obstructive Pulmonary Disease
Hepatitis
Ulcer
Comorbidity
Cell Survival
Phosphorylation
Insulin

Keywords

  • Cardiomyoblasts
  • Chinese herbal medicine
  • Ischemic heart disease
  • Oxidative stress
  • Type 2 diabetes

ASJC Scopus subject areas

  • Oncology

Cite this

Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts. / Tsai, Fuu Jen; Ho, Tsung Jung; Cheng, Chi Fung; Shiao, Yi Tzone; Chien, Wen Kuei; Chen, Jin Hua; Liu, Xiang; Tsang, Hsinyi; Lin, Ting Hsu; Liao, Chiu Chu; Huang, Shao Mei; Li, Ju Pi; Lin, Cheng Wen; Lin, Jaung Geng; Lan, Yu Ching; Liu, Yu Huei; Hung, Chien Hui; Lin, Jung Chun; Lin, Chih Chien; Lai, Chih Ho; Liang, Wen Miin; Lin, Ying Ju.

In: Oncotarget, Vol. 8, No. 9, 2017, p. 15470-15489.

Research output: Contribution to journalArticle

Tsai, FJ, Ho, TJ, Cheng, CF, Shiao, YT, Chien, WK, Chen, JH, Liu, X, Tsang, H, Lin, TH, Liao, CC, Huang, SM, Li, JP, Lin, CW, Lin, JG, Lan, YC, Liu, YH, Hung, CH, Lin, JC, Lin, CC, Lai, CH, Liang, WM & Lin, YJ 2017, 'Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts', Oncotarget, vol. 8, no. 9, pp. 15470-15489. https://doi.org/10.18632/oncotarget.14657
Tsai, Fuu Jen ; Ho, Tsung Jung ; Cheng, Chi Fung ; Shiao, Yi Tzone ; Chien, Wen Kuei ; Chen, Jin Hua ; Liu, Xiang ; Tsang, Hsinyi ; Lin, Ting Hsu ; Liao, Chiu Chu ; Huang, Shao Mei ; Li, Ju Pi ; Lin, Cheng Wen ; Lin, Jaung Geng ; Lan, Yu Ching ; Liu, Yu Huei ; Hung, Chien Hui ; Lin, Jung Chun ; Lin, Chih Chien ; Lai, Chih Ho ; Liang, Wen Miin ; Lin, Ying Ju. / Characteristics of Chinese herbal medicine usage in ischemic heart disease patients among type 2 diabetes and their protection against hydrogen peroxide-mediated apoptosis in H9C2 cardiomyoblasts. In: Oncotarget. 2017 ; Vol. 8, No. 9. pp. 15470-15489.
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AU - Shiao, Yi Tzone

AU - Chien, Wen Kuei

AU - Chen, Jin Hua

AU - Liu, Xiang

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AU - Lin, Cheng Wen

AU - Lin, Jaung Geng

AU - Lan, Yu Ching

AU - Liu, Yu Huei

AU - Hung, Chien Hui

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