Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

Chen Ying Su, Chia Chun Chen, Hsuan Yu Chen, Chun Pin Lin, Feng Huei Lin, Hsu Wei Fang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.

Original languageEnglish
Pages (from-to)192-197
Number of pages6
JournalJournal of Dental Sciences
Volume14
Issue number2
DOIs
Publication statusPublished - Jun 1 2019
Externally publishedYes

Fingerprint

Mouthwashes
Biocompatible Materials
Prostaglandins A
Alcohols
Pseudomonas aeruginosa
Staphylococcus aureus
Cell Survival
Escherichia coli
Growth

Keywords

  • Biomaterials
  • Mouthwash
  • Poly-gamma-glutamic acid (γ-PGA)

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol. / Su, Chen Ying; Chen, Chia Chun; Chen, Hsuan Yu; Lin, Chun Pin; Lin, Feng Huei; Fang, Hsu Wei.

In: Journal of Dental Sciences, Vol. 14, No. 2, 01.06.2019, p. 192-197.

Research output: Contribution to journalArticle

Su, Chen Ying ; Chen, Chia Chun ; Chen, Hsuan Yu ; Lin, Chun Pin ; Lin, Feng Huei ; Fang, Hsu Wei. / Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol. In: Journal of Dental Sciences. 2019 ; Vol. 14, No. 2. pp. 192-197.
@article{e6f131f0e5f142fe9faa16651160ca6a,
title = "Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol",
abstract = "Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99{\%} of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.",
keywords = "Biomaterials, Mouthwash, Poly-gamma-glutamic acid (γ-PGA)",
author = "Su, {Chen Ying} and Chen, {Chia Chun} and Chen, {Hsuan Yu} and Lin, {Chun Pin} and Lin, {Feng Huei} and Fang, {Hsu Wei}",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.jds.2019.01.002",
language = "English",
volume = "14",
pages = "192--197",
journal = "Journal of Dental Sciences",
issn = "1991-7902",
publisher = "中華牙醫學會",
number = "2",

}

TY - JOUR

T1 - Characteristics of an alternative antibacterial biomaterial for mouthwash in the absence of alcohol

AU - Su, Chen Ying

AU - Chen, Chia Chun

AU - Chen, Hsuan Yu

AU - Lin, Chun Pin

AU - Lin, Feng Huei

AU - Fang, Hsu Wei

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.

AB - Background/purpose: The purpose of this study was to investigate whether poly-gamma-glutamic acid (γ-PGA), a naturally derived biomaterial, was suitable as an alternative antibacterial mouthwash in the absence of alcohol. Materials and methods: Three bacterial strains, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, were used for testing the antibacterial activity of mouthwashes. In addition, cell viability, cytotoxicity, and genotoxicity experiments were conducted for testing the toxicity of mouthwashes. Results: We demonstrated that 10000 ppm of γ-PGA without alcohol could efficiently inhibit 99% of bacterial growth. In addition, γ-PGA did not cause any cytotoxicity or genotoxicity. Conclusion: 10000 ppm of γ-PGA in an alcohol-free mouthwash is an alternative biomaterial for mouthwashes.

KW - Biomaterials

KW - Mouthwash

KW - Poly-gamma-glutamic acid (γ-PGA)

UR - http://www.scopus.com/inward/record.url?scp=85063114556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063114556&partnerID=8YFLogxK

U2 - 10.1016/j.jds.2019.01.002

DO - 10.1016/j.jds.2019.01.002

M3 - Article

AN - SCOPUS:85063114556

VL - 14

SP - 192

EP - 197

JO - Journal of Dental Sciences

JF - Journal of Dental Sciences

SN - 1991-7902

IS - 2

ER -