Characteristics of acoustic wave propagation in dermis for the diagnosis of the superficial tissue damage in radiation therapy

Chung Wei Lyu, Hsian-Jenn Wang, Lee Cheng Peng, Chien Chou

Research output: Contribution to journalConference articlepeer-review

1 Citation (Scopus)

Abstract

Measurement of tissue radiation damage quantitatively in radiation therapy is very important to optimize the therapeutic treatment. Ionized radiation induces homogenization of the extracellular matrix which is synthesized by fibroblast and the randomization of the orientation of the collagen fibers in dermis. If the dermis is exposed by ionized radiation, a thermal acoustic shear wave which propagates in dermis becomes harmonic wave; Otherwise, an inharmonic wave is expected because of inhomogeneous and the anisotropic properties of dermis. A polarized optical heterodyne interferometer was setup in order to measure the transverse displacement of the shear wave in order to analyze the propagation mode of the shear wave in dermis. The detection sensitivity of the displacement was 1 nm and the dynamic range was 300 nm in this arrangement. The lowest dose that can be detected by the exposure of 4 MeV radiation on porcine dermis was 1 cGy.

Original languageEnglish
Pages (from-to)248-254
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4082
Publication statusPublished - Jan 1 2000
Externally publishedYes
EventOptical Sensing, Imaging, and Manipulation for Biological and Biomedical Applications - Taipei, Taiwan
Duration: Jul 26 2000Jul 28 2000

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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