Characteristics and antioxidant activities of silymarin nanoparticles

Wen Chan Hsu, Lean Teik Ng, Tzu Hui Wu, Liang Tzung Lin, Feng Lin Yen, Chun Ching Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Silymarin, a well known hepatoprotective drug, has been routinely used in treating liver disorders. However, its bioavailability and therapeutic efficiency are limited by the poor aqueous solubility. In this study, we used the nanoprecipitation technique to develop a nanoparticles system to improve the solubility of silymarin. The newly developed silymarin nanoparticles were characterized for mean particle size, morphology, intermolecular interaction, crystalline features and dissolution property, as well as assessing for antioxidant activities. Results indicated that a drastic change in the physiochemical properties of silymarin was noted in the form of nanoparticles, as displayed by the extremely small particle size (46.1±1.73 nm), the formation of intermolecular hydrogen bonding between silymarin and matrix of nanoparticles, and the rendering of amorphous state. These phenomena have contributed to the enhanced dissolution property of silymarin nanoparticles, as well as a greater potency in DPPH radical scavenging, anti-superoxide anion formation, and superoxide anion scavenging activities than the crude silymarin. The present study concludes that silymarin nanoparticles have an improved physicochemical property as demonstrated by an increased solubility and enhanced antioxidant activities.

Original languageEnglish
Pages (from-to)2022-2027
Number of pages6
JournalJournal of Nanoscience and Nanotechnology
Volume12
Issue number3
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Antioxidant
  • Nanoparticle
  • Silymarin
  • Solubility

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Chemistry(all)
  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering

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