Characterisation and molecular epidemiology of extended-spectrum β-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan

Wen-Liang Yu, Kuo-Chen Cheng, Chizh Ju Chi, Hui E. Chen, Yin Ching Chuang, Lii Tzu Wu

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Enterobacter cloacae (n = 110) isolates from a district hospital in Taiwan were screened for extended-spectrum β-lactamases (ESBLs). In total, 17 ESBL-producers were identified, based on the combination-disk synergy test using cefotaxime and ceftazidime ± clavulanic acid. Investigation of ESBL genes in 33 ceftazidime-resistant isolates revealed the SHV-12 gene in the same 17 ESBL-producers. In addition, one isolate also carried the CTX-M-3 gene, and two isolates also carried the CTX-M-9 gene. No major epidemic clone of ESBL-producers was identified by pulsed-field gel electrophoresis. Routine screening for the ESBL phenotype, focusing on ceftazidime-resistant E. cloacae, should be undertaken in this area.

Original languageEnglish
Pages (from-to)579-582
Number of pages4
JournalClinical Microbiology and Infection
Issue number6
Publication statusPublished - Jun 2006



  • CTX-M-3
  • CTX-M-9
  • Enterobacter cloacae
  • Extended-spectrum β-lactamases
  • SHV-12

ASJC Scopus subject areas

  • Microbiology (medical)
  • Microbiology

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