Chapter 8: Role of kynurenine pathway in allergy

Hirokazu Kawasaki, Shau Ku Huang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

Original languageEnglish
Title of host publicationTargeting the Broadly Pathogenic Kynurenine Pathway
PublisherSpringer International Publishing
Pages109-119
Number of pages11
ISBN (Electronic)9783319118703
ISBN (Print)9783319118697
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

Fingerprint

Allergies
Kynurenine
Tryptophan
Hypersensitivity
Metabolites
Aryl Hydrocarbon Receptors
Chemical sensors
Immunotherapy
Allergens
Modulation
Degradation
Therapeutics

Keywords

  • Allergen-specifi c immunotherapy
  • Allergic diseases
  • Allergy
  • Aryl hydrocarbon receptor
  • Immune tolerance
  • Kynurenine
  • Mast cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Neuroscience(all)

Cite this

Kawasaki, H., & Huang, S. K. (2015). Chapter 8: Role of kynurenine pathway in allergy. In Targeting the Broadly Pathogenic Kynurenine Pathway (pp. 109-119). Springer International Publishing. https://doi.org/10.1007/978-3-319-11870-3_8

Chapter 8 : Role of kynurenine pathway in allergy. / Kawasaki, Hirokazu; Huang, Shau Ku.

Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 2015. p. 109-119.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kawasaki, H & Huang, SK 2015, Chapter 8: Role of kynurenine pathway in allergy. in Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, pp. 109-119. https://doi.org/10.1007/978-3-319-11870-3_8
Kawasaki H, Huang SK. Chapter 8: Role of kynurenine pathway in allergy. In Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing. 2015. p. 109-119 https://doi.org/10.1007/978-3-319-11870-3_8
Kawasaki, Hirokazu ; Huang, Shau Ku. / Chapter 8 : Role of kynurenine pathway in allergy. Targeting the Broadly Pathogenic Kynurenine Pathway. Springer International Publishing, 2015. pp. 109-119
@inbook{ad53bca9d36645b4bafd72b151d00af8,
title = "Chapter 8: Role of kynurenine pathway in allergy",
abstract = "Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.",
keywords = "Allergen-specifi c immunotherapy, Allergic diseases, Allergy, Aryl hydrocarbon receptor, Immune tolerance, Kynurenine, Mast cells",
author = "Hirokazu Kawasaki and Huang, {Shau Ku}",
year = "2015",
month = "1",
day = "1",
doi = "10.1007/978-3-319-11870-3_8",
language = "English",
isbn = "9783319118697",
pages = "109--119",
booktitle = "Targeting the Broadly Pathogenic Kynurenine Pathway",
publisher = "Springer International Publishing",

}

TY - CHAP

T1 - Chapter 8

T2 - Role of kynurenine pathway in allergy

AU - Kawasaki, Hirokazu

AU - Huang, Shau Ku

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

AB - Tryptophan catabolism, including kynurenine pathway, is known to be involved in immunoregulation and its metabolites play a role in immune modulation. In the context of allergic diseases, it has been proposed that tryptophan degradation pathway, rather than tryptophan deprivation itself, plays an important role in tolerance induction during allergen-specifi c immunotherapy, which is, by far, the only causal treatment of allergic diseases. In addition, it has recently been demonstrated that kynurenine and, perhaps, its metabolites can act through the aryl hydrocarbon receptor, a unique cellular chemical sensor, and regulate immune functions. The present review intends to highlight the recent development on the involvement of kynurenine pathway in the regulation of allergic diseases.

KW - Allergen-specifi c immunotherapy

KW - Allergic diseases

KW - Allergy

KW - Aryl hydrocarbon receptor

KW - Immune tolerance

KW - Kynurenine

KW - Mast cells

UR - http://www.scopus.com/inward/record.url?scp=84957033055&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84957033055&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-11870-3_8

DO - 10.1007/978-3-319-11870-3_8

M3 - Chapter

AN - SCOPUS:84957033055

SN - 9783319118697

SP - 109

EP - 119

BT - Targeting the Broadly Pathogenic Kynurenine Pathway

PB - Springer International Publishing

ER -