Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006-2007

Chien Feng Li, Meei Fang Liu, Zhi Yuan Shi, Po Ren Hsueh, Chun Hsing Liao, Tsrang Neng Jang, Shih Ming Tsao, Hsiang Chi Kung, Gwo Jong Hsu, Yu Jen Cheng, Hsiu Chen Lin, Yung Ching Liu, Yin Ching Chuang, Lih Shinn Wang, Chih Ming Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: Multiple antibiotic-resistant clones of Streptococcus pneumoniae have spread throughout the world and continue to evolve under the selective pressure of antibiotics and vaccines. The aim of this study is to assess the susceptibility of S. pneumoniae isolates and to analyze the resistance trends in Taiwan. Methods: Antimicrobial susceptibility tests were performed on 152 nonmeningeal isolates of S. pneumoniae that were collected from 13 different hospitals around Taiwan from 2006-2007. Tests were performed using the broth microdilution method according to recommendations of the Clinical and Laboratory Standards Institute. Results: The minimal inhibitory concentrations (MIC50/MIC90) of penicillin, cefotaxime, vancomycin, and moxifloxacin were 0.5/1.0, 0.25/1.0, 0.25/0.5, and 0.06/0.12 μg/mL, respectively. The susceptibility rates of penicillin, cefotaxime, vancomycin, and moxifloxacin were 99.3%, 99.3%, 100%, and 98.7%, respectively. However, if the meningitis breakpoints were applied to these nonmeningeal isolates, the susceptibility rates of penicillin and cefotaxime were reduced to 18.4% and 76.3%, respectively. Compared with the findings from previous studies in Taiwan, our results show that the percentage of S. pneumoniae isolates with a penicillin MIC of 0.12-1.0 μg/mL increased from 43.3% in 1996-1997 to 73.7% in 2006-2007 (p <0.001). The percentage of S. pneumoniae isolates with a cefotaxime MIC of 1.0 μg/mL increased from 11.3% in 1996-1997 to 23.0% in 2006-2007 (p <0.001). Regarding the serial MIC intervals of the four antimicrobial agents, there was no significant difference between bacteremic and nonbacteremic isolates. Conclusion: Although nonmeningeal S. pneumoniae isolates remained susceptible to penicillin, the proportion of isolates with a penicillin MIC of 0.12-1.0 μg/mL or cefotaxime MIC of 1.0 μg/mL increased during the past decade in Taiwan. The ever-increasing resistance of S. pneumoniae has a great impact on the treatment of meningitis.

Original languageEnglish
Pages (from-to)305-310
Number of pages6
JournalJournal of Microbiology, Immunology and Infection
Volume45
Issue number4
DOIs
Publication statusPublished - Aug 2012
Externally publishedYes

Fingerprint

Streptococcus pneumoniae
Taiwan
Cefotaxime
Penicillins
Vancomycin
Meningitis
Anti-Bacterial Agents
Anti-Infective Agents
Vaccines
Clone Cells

Keywords

  • Antimicrobial susceptibility
  • Streptococcus pneumoniae
  • Taiwan

ASJC Scopus subject areas

  • Microbiology (medical)
  • Immunology and Allergy
  • Immunology and Microbiology(all)
  • Infectious Diseases

Cite this

Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006-2007. / Li, Chien Feng; Liu, Meei Fang; Shi, Zhi Yuan; Hsueh, Po Ren; Liao, Chun Hsing; Jang, Tsrang Neng; Tsao, Shih Ming; Kung, Hsiang Chi; Hsu, Gwo Jong; Cheng, Yu Jen; Lin, Hsiu Chen; Liu, Yung Ching; Chuang, Yin Ching; Wang, Lih Shinn; Chen, Chih Ming.

In: Journal of Microbiology, Immunology and Infection, Vol. 45, No. 4, 08.2012, p. 305-310.

Research output: Contribution to journalArticle

Li, CF, Liu, MF, Shi, ZY, Hsueh, PR, Liao, CH, Jang, TN, Tsao, SM, Kung, HC, Hsu, GJ, Cheng, YJ, Lin, HC, Liu, YC, Chuang, YC, Wang, LS & Chen, CM 2012, 'Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006-2007', Journal of Microbiology, Immunology and Infection, vol. 45, no. 4, pp. 305-310. https://doi.org/10.1016/j.jmii.2011.12.012
Li, Chien Feng ; Liu, Meei Fang ; Shi, Zhi Yuan ; Hsueh, Po Ren ; Liao, Chun Hsing ; Jang, Tsrang Neng ; Tsao, Shih Ming ; Kung, Hsiang Chi ; Hsu, Gwo Jong ; Cheng, Yu Jen ; Lin, Hsiu Chen ; Liu, Yung Ching ; Chuang, Yin Ching ; Wang, Lih Shinn ; Chen, Chih Ming. / Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006-2007. In: Journal of Microbiology, Immunology and Infection. 2012 ; Vol. 45, No. 4. pp. 305-310.
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abstract = "Background: Multiple antibiotic-resistant clones of Streptococcus pneumoniae have spread throughout the world and continue to evolve under the selective pressure of antibiotics and vaccines. The aim of this study is to assess the susceptibility of S. pneumoniae isolates and to analyze the resistance trends in Taiwan. Methods: Antimicrobial susceptibility tests were performed on 152 nonmeningeal isolates of S. pneumoniae that were collected from 13 different hospitals around Taiwan from 2006-2007. Tests were performed using the broth microdilution method according to recommendations of the Clinical and Laboratory Standards Institute. Results: The minimal inhibitory concentrations (MIC50/MIC90) of penicillin, cefotaxime, vancomycin, and moxifloxacin were 0.5/1.0, 0.25/1.0, 0.25/0.5, and 0.06/0.12 μg/mL, respectively. The susceptibility rates of penicillin, cefotaxime, vancomycin, and moxifloxacin were 99.3{\%}, 99.3{\%}, 100{\%}, and 98.7{\%}, respectively. However, if the meningitis breakpoints were applied to these nonmeningeal isolates, the susceptibility rates of penicillin and cefotaxime were reduced to 18.4{\%} and 76.3{\%}, respectively. Compared with the findings from previous studies in Taiwan, our results show that the percentage of S. pneumoniae isolates with a penicillin MIC of 0.12-1.0 μg/mL increased from 43.3{\%} in 1996-1997 to 73.7{\%} in 2006-2007 (p <0.001). The percentage of S. pneumoniae isolates with a cefotaxime MIC of 1.0 μg/mL increased from 11.3{\%} in 1996-1997 to 23.0{\%} in 2006-2007 (p <0.001). Regarding the serial MIC intervals of the four antimicrobial agents, there was no significant difference between bacteremic and nonbacteremic isolates. Conclusion: Although nonmeningeal S. pneumoniae isolates remained susceptible to penicillin, the proportion of isolates with a penicillin MIC of 0.12-1.0 μg/mL or cefotaxime MIC of 1.0 μg/mL increased during the past decade in Taiwan. The ever-increasing resistance of S. pneumoniae has a great impact on the treatment of meningitis.",
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T1 - Changing trends in antimicrobial susceptibility of Streptococcus pneumoniae isolates in Taiwan, 2006-2007

AU - Li, Chien Feng

AU - Liu, Meei Fang

AU - Shi, Zhi Yuan

AU - Hsueh, Po Ren

AU - Liao, Chun Hsing

AU - Jang, Tsrang Neng

AU - Tsao, Shih Ming

AU - Kung, Hsiang Chi

AU - Hsu, Gwo Jong

AU - Cheng, Yu Jen

AU - Lin, Hsiu Chen

AU - Liu, Yung Ching

AU - Chuang, Yin Ching

AU - Wang, Lih Shinn

AU - Chen, Chih Ming

PY - 2012/8

Y1 - 2012/8

N2 - Background: Multiple antibiotic-resistant clones of Streptococcus pneumoniae have spread throughout the world and continue to evolve under the selective pressure of antibiotics and vaccines. The aim of this study is to assess the susceptibility of S. pneumoniae isolates and to analyze the resistance trends in Taiwan. Methods: Antimicrobial susceptibility tests were performed on 152 nonmeningeal isolates of S. pneumoniae that were collected from 13 different hospitals around Taiwan from 2006-2007. Tests were performed using the broth microdilution method according to recommendations of the Clinical and Laboratory Standards Institute. Results: The minimal inhibitory concentrations (MIC50/MIC90) of penicillin, cefotaxime, vancomycin, and moxifloxacin were 0.5/1.0, 0.25/1.0, 0.25/0.5, and 0.06/0.12 μg/mL, respectively. The susceptibility rates of penicillin, cefotaxime, vancomycin, and moxifloxacin were 99.3%, 99.3%, 100%, and 98.7%, respectively. However, if the meningitis breakpoints were applied to these nonmeningeal isolates, the susceptibility rates of penicillin and cefotaxime were reduced to 18.4% and 76.3%, respectively. Compared with the findings from previous studies in Taiwan, our results show that the percentage of S. pneumoniae isolates with a penicillin MIC of 0.12-1.0 μg/mL increased from 43.3% in 1996-1997 to 73.7% in 2006-2007 (p <0.001). The percentage of S. pneumoniae isolates with a cefotaxime MIC of 1.0 μg/mL increased from 11.3% in 1996-1997 to 23.0% in 2006-2007 (p <0.001). Regarding the serial MIC intervals of the four antimicrobial agents, there was no significant difference between bacteremic and nonbacteremic isolates. Conclusion: Although nonmeningeal S. pneumoniae isolates remained susceptible to penicillin, the proportion of isolates with a penicillin MIC of 0.12-1.0 μg/mL or cefotaxime MIC of 1.0 μg/mL increased during the past decade in Taiwan. The ever-increasing resistance of S. pneumoniae has a great impact on the treatment of meningitis.

AB - Background: Multiple antibiotic-resistant clones of Streptococcus pneumoniae have spread throughout the world and continue to evolve under the selective pressure of antibiotics and vaccines. The aim of this study is to assess the susceptibility of S. pneumoniae isolates and to analyze the resistance trends in Taiwan. Methods: Antimicrobial susceptibility tests were performed on 152 nonmeningeal isolates of S. pneumoniae that were collected from 13 different hospitals around Taiwan from 2006-2007. Tests were performed using the broth microdilution method according to recommendations of the Clinical and Laboratory Standards Institute. Results: The minimal inhibitory concentrations (MIC50/MIC90) of penicillin, cefotaxime, vancomycin, and moxifloxacin were 0.5/1.0, 0.25/1.0, 0.25/0.5, and 0.06/0.12 μg/mL, respectively. The susceptibility rates of penicillin, cefotaxime, vancomycin, and moxifloxacin were 99.3%, 99.3%, 100%, and 98.7%, respectively. However, if the meningitis breakpoints were applied to these nonmeningeal isolates, the susceptibility rates of penicillin and cefotaxime were reduced to 18.4% and 76.3%, respectively. Compared with the findings from previous studies in Taiwan, our results show that the percentage of S. pneumoniae isolates with a penicillin MIC of 0.12-1.0 μg/mL increased from 43.3% in 1996-1997 to 73.7% in 2006-2007 (p <0.001). The percentage of S. pneumoniae isolates with a cefotaxime MIC of 1.0 μg/mL increased from 11.3% in 1996-1997 to 23.0% in 2006-2007 (p <0.001). Regarding the serial MIC intervals of the four antimicrobial agents, there was no significant difference between bacteremic and nonbacteremic isolates. Conclusion: Although nonmeningeal S. pneumoniae isolates remained susceptible to penicillin, the proportion of isolates with a penicillin MIC of 0.12-1.0 μg/mL or cefotaxime MIC of 1.0 μg/mL increased during the past decade in Taiwan. The ever-increasing resistance of S. pneumoniae has a great impact on the treatment of meningitis.

KW - Antimicrobial susceptibility

KW - Streptococcus pneumoniae

KW - Taiwan

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