Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy

Shu Ching Chen, Yeur Hur Lai, Chun Ta Liao, Chia-Chin Lin, Joseph Tung Chien Chang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The purposes of this study were to (1) examine changes in symptom severity and depression within 3 months of first undergoing radiation therapy (RT) or concurrent chemoradiation therapy (CCRT), and (2) identify factors involved in changes in symptom severity in newly diagnosed oral cavity cancer patients undergoing post-operative RT or CCRT. A prospective panel survey was conducted to assess changes in symptoms, depression, and disease- or treatment-related characteristics within 3 months of beginning RT or CCRT (pre-treatment and 1, 2, and 3 months from first receiving RT). A total of 76 eligible oral cavity cancer patients were recruited from the outpatient radiation department of a medical center in northern Taiwan. The results showed mild-to-moderate overall symptom and depression levels during treatment, with the five most distressing symptoms being swallowing difficulty, poor appetite, oral mucositis, pain, and fatigue. The severity of symptoms and depression peaked at ∼2 months from beginning RT or CCRT (T3). Changes in overall symptom severity were found to be significantly related to patients' radiation dose and depression level. These results can help advance understanding of changes in symptoms and facilitate prevention and management of symptoms associated with RT or CCRT. Psychological distress, particularly, depression, requires careful monitoring and management in oral cavity cancer patients undergoing RT or CCRT.

Original languageEnglish
Pages (from-to)509-513
Number of pages5
JournalOral Oncology
Volume46
Issue number7
DOIs
Publication statusPublished - Jul 2010

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Mouth Neoplasms
Mouth
Radiotherapy
Depression
Therapeutics
Radiation
Stomatitis
Appetite
Deglutition
Taiwan
Fatigue
Outpatients
Psychology
Pain

Keywords

  • Depression
  • Oral cavity cancer
  • Post-operative
  • Radiation
  • Symptom

ASJC Scopus subject areas

  • Oncology
  • Oral Surgery
  • Cancer Research

Cite this

Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy. / Chen, Shu Ching; Lai, Yeur Hur; Liao, Chun Ta; Lin, Chia-Chin; Chang, Joseph Tung Chien.

In: Oral Oncology, Vol. 46, No. 7, 07.2010, p. 509-513.

Research output: Contribution to journalArticle

Chen, Shu Ching ; Lai, Yeur Hur ; Liao, Chun Ta ; Lin, Chia-Chin ; Chang, Joseph Tung Chien. / Changes of symptoms and depression in oral cavity cancer patients receiving radiation therapy. In: Oral Oncology. 2010 ; Vol. 46, No. 7. pp. 509-513.
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