Changes of Serum Cortisol and Thyroid Hormones after Irradiation

Wen-Sheng Huang, 鄧 文炳(Win-Ping Deng), Ching-Yuan Chen, Ying-Kai Fu, Ping-Cheng Yang, Cheng-Yi Cheng

Research output: Contribution to journalArticle

Abstract

Background: Both cortisol and thyroid hormones were sought to be stress hormones in critical illnesses which are readily measurable in a clinical setting. The investigation was to sequentially observe the changes in these hormone levels in pigs after acute radiation exposure. Methods: Six 27-week-old SPF miniature pigs were divided into 2 groups. The irradiated (non- survival) group (n =4) received 12 Gy of 60Co whole body γ-irradiation only and all died within 3 weeks after irradiation. The non-irradiated group C (n=2) served as control. Serial blood samples were drawn at the same time the day before and weekly after irradiation for 7 weeks. Results: A trend of progressive decline of both serum T3 and T4 values after irradiation was found. A rapid drop of serum tri-iodothyronine (T3) values was found in the irradiated groups, which is reaching the nadir within 10 days post-irradiation. There was a profound decrease of T4 values in the irradiated group days before death (all <23 nmol/L, 49% mean decrease before death, control, 31-44 nmol/L). Changes of serum cortisol values were rather inconsistent in irradiated groups. There was a surge of serum cortisol value in the irradiated group within 2 days before death (167 ± 122 vs. 453 ± 177 nmol/L; P<0.01) that was not found in the control group (195±34 nmol/L). Conclusion: Serial monitoring serum T3, T4 and cortisol values may be a feasible indicator of the severity of acute radiation events. Dropped T3 levels appeared to be a sensitive marker to reflect the presence of sickness while the degree of decrease of serum T4 levels may represent the severity of sickness. A surge of serum cortisol value may indicate a fatal outcome.
Original languageUndefined/Unknown
Pages (from-to)197-202
Number of pages6
Journal核子醫學雜誌
Volume16
Issue number4
DOIs
Publication statusPublished - 2003

Keywords

  • thyroid hormones
  • cortisol
  • irradiation

Cite this

Changes of Serum Cortisol and Thyroid Hormones after Irradiation. / Huang, Wen-Sheng; 鄧文炳(Win-Ping Deng); Chen, Ching-Yuan; Fu, Ying-Kai; Yang, Ping-Cheng; Cheng, Cheng-Yi.

In: 核子醫學雜誌, Vol. 16, No. 4, 2003, p. 197-202.

Research output: Contribution to journalArticle

Huang, W-S, 鄧文炳(Win-PingD, Chen, C-Y, Fu, Y-K, Yang, P-C & Cheng, C-Y 2003, 'Changes of Serum Cortisol and Thyroid Hormones after Irradiation', 核子醫學雜誌, vol. 16, no. 4, pp. 197-202. https://doi.org/10.6332/ANMS.1604.007
Huang, Wen-Sheng ; 鄧文炳(Win-Ping Deng) ; Chen, Ching-Yuan ; Fu, Ying-Kai ; Yang, Ping-Cheng ; Cheng, Cheng-Yi. / Changes of Serum Cortisol and Thyroid Hormones after Irradiation. In: 核子醫學雜誌. 2003 ; Vol. 16, No. 4. pp. 197-202.
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abstract = "Background: Both cortisol and thyroid hormones were sought to be stress hormones in critical illnesses which are readily measurable in a clinical setting. The investigation was to sequentially observe the changes in these hormone levels in pigs after acute radiation exposure. Methods: Six 27-week-old SPF miniature pigs were divided into 2 groups. The irradiated (non- survival) group (n =4) received 12 Gy of 60Co whole body γ-irradiation only and all died within 3 weeks after irradiation. The non-irradiated group C (n=2) served as control. Serial blood samples were drawn at the same time the day before and weekly after irradiation for 7 weeks. Results: A trend of progressive decline of both serum T3 and T4 values after irradiation was found. A rapid drop of serum tri-iodothyronine (T3) values was found in the irradiated groups, which is reaching the nadir within 10 days post-irradiation. There was a profound decrease of T4 values in the irradiated group days before death (all <23 nmol/L, 49{\%} mean decrease before death, control, 31-44 nmol/L). Changes of serum cortisol values were rather inconsistent in irradiated groups. There was a surge of serum cortisol value in the irradiated group within 2 days before death (167 ± 122 vs. 453 ± 177 nmol/L; P<0.01) that was not found in the control group (195±34 nmol/L). Conclusion: Serial monitoring serum T3, T4 and cortisol values may be a feasible indicator of the severity of acute radiation events. Dropped T3 levels appeared to be a sensitive marker to reflect the presence of sickness while the degree of decrease of serum T4 levels may represent the severity of sickness. A surge of serum cortisol value may indicate a fatal outcome.",
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TY - JOUR

T1 - Changes of Serum Cortisol and Thyroid Hormones after Irradiation

AU - Huang, Wen-Sheng

AU - 鄧, 文炳(Win-Ping Deng)

AU - Chen, Ching-Yuan

AU - Fu, Ying-Kai

AU - Yang, Ping-Cheng

AU - Cheng, Cheng-Yi

PY - 2003

Y1 - 2003

N2 - Background: Both cortisol and thyroid hormones were sought to be stress hormones in critical illnesses which are readily measurable in a clinical setting. The investigation was to sequentially observe the changes in these hormone levels in pigs after acute radiation exposure. Methods: Six 27-week-old SPF miniature pigs were divided into 2 groups. The irradiated (non- survival) group (n =4) received 12 Gy of 60Co whole body γ-irradiation only and all died within 3 weeks after irradiation. The non-irradiated group C (n=2) served as control. Serial blood samples were drawn at the same time the day before and weekly after irradiation for 7 weeks. Results: A trend of progressive decline of both serum T3 and T4 values after irradiation was found. A rapid drop of serum tri-iodothyronine (T3) values was found in the irradiated groups, which is reaching the nadir within 10 days post-irradiation. There was a profound decrease of T4 values in the irradiated group days before death (all <23 nmol/L, 49% mean decrease before death, control, 31-44 nmol/L). Changes of serum cortisol values were rather inconsistent in irradiated groups. There was a surge of serum cortisol value in the irradiated group within 2 days before death (167 ± 122 vs. 453 ± 177 nmol/L; P<0.01) that was not found in the control group (195±34 nmol/L). Conclusion: Serial monitoring serum T3, T4 and cortisol values may be a feasible indicator of the severity of acute radiation events. Dropped T3 levels appeared to be a sensitive marker to reflect the presence of sickness while the degree of decrease of serum T4 levels may represent the severity of sickness. A surge of serum cortisol value may indicate a fatal outcome.

AB - Background: Both cortisol and thyroid hormones were sought to be stress hormones in critical illnesses which are readily measurable in a clinical setting. The investigation was to sequentially observe the changes in these hormone levels in pigs after acute radiation exposure. Methods: Six 27-week-old SPF miniature pigs were divided into 2 groups. The irradiated (non- survival) group (n =4) received 12 Gy of 60Co whole body γ-irradiation only and all died within 3 weeks after irradiation. The non-irradiated group C (n=2) served as control. Serial blood samples were drawn at the same time the day before and weekly after irradiation for 7 weeks. Results: A trend of progressive decline of both serum T3 and T4 values after irradiation was found. A rapid drop of serum tri-iodothyronine (T3) values was found in the irradiated groups, which is reaching the nadir within 10 days post-irradiation. There was a profound decrease of T4 values in the irradiated group days before death (all <23 nmol/L, 49% mean decrease before death, control, 31-44 nmol/L). Changes of serum cortisol values were rather inconsistent in irradiated groups. There was a surge of serum cortisol value in the irradiated group within 2 days before death (167 ± 122 vs. 453 ± 177 nmol/L; P<0.01) that was not found in the control group (195±34 nmol/L). Conclusion: Serial monitoring serum T3, T4 and cortisol values may be a feasible indicator of the severity of acute radiation events. Dropped T3 levels appeared to be a sensitive marker to reflect the presence of sickness while the degree of decrease of serum T4 levels may represent the severity of sickness. A surge of serum cortisol value may indicate a fatal outcome.

KW - thyroid hormones

KW - cortisol

KW - irradiation

KW - 甲狀腺激素

KW - 皮質醇

KW - 輻射曝露

U2 - 10.6332/ANMS.1604.007

DO - 10.6332/ANMS.1604.007

M3 - 文章

VL - 16

SP - 197

EP - 202

JO - 核子醫學雜誌

JF - 核子醫學雜誌

SN - 1022-923X

IS - 4

ER -