Changes in T-cell subsets after radiation therapy

S. Yang, S. Rafla, E. Youssef, H. Selim, N. Salloum, J. Y. Chuang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The T-cell subsets of 129 patients with cancer were counted before and after radiation therapy. The cells were labeled with monoclonal antibodies that were specific for each type of T cell. Significant changes after therapy were decreases in the proportion of T-helper/inducer cells, pan-T cells, and in the ratio of T-helper/inducer to T-suppressor/cytotoxic cells. There was an increase in the percentage of T-suppressor/cytotoxic cells. When the site of the primary cancer was considered, genitourinary cancer and cancer of the head and neck both showed a decreased percentage of T-helper/inducer cells and a reduced ratio of T-helper/inducer to T-suppressor/cytotoxic cells. The percentage of pan-T cells in head and neck cancer and the ratio of T-helper/inducer to T-suppressor/cytotoxic cells in breast cancer were decreased. The percentage of T-helper cells was particularly decreased by radiation therapy in advanced stages of cancer, in higher grade tumors, and in larger tumors. The absolute numbers of various T-cell subsets were decreased in all groups.

Original languageEnglish
Pages (from-to)537-540
Number of pages4
JournalRadiology
Volume168
Issue number2
DOIs
Publication statusPublished - Jan 1 1988
Externally publishedYes

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T-Lymphocyte Subsets
Radiotherapy
Helper-Inducer T-Lymphocytes
Neoplasms
Head and Neck Neoplasms
T-Lymphocytes
Urogenital Neoplasms
Monoclonal Antibodies
Breast Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Yang, S., Rafla, S., Youssef, E., Selim, H., Salloum, N., & Chuang, J. Y. (1988). Changes in T-cell subsets after radiation therapy. Radiology, 168(2), 537-540. https://doi.org/10.1148/radiology.168.2.3260678

Changes in T-cell subsets after radiation therapy. / Yang, S.; Rafla, S.; Youssef, E.; Selim, H.; Salloum, N.; Chuang, J. Y.

In: Radiology, Vol. 168, No. 2, 01.01.1988, p. 537-540.

Research output: Contribution to journalArticle

Yang, S, Rafla, S, Youssef, E, Selim, H, Salloum, N & Chuang, JY 1988, 'Changes in T-cell subsets after radiation therapy', Radiology, vol. 168, no. 2, pp. 537-540. https://doi.org/10.1148/radiology.168.2.3260678
Yang S, Rafla S, Youssef E, Selim H, Salloum N, Chuang JY. Changes in T-cell subsets after radiation therapy. Radiology. 1988 Jan 1;168(2):537-540. https://doi.org/10.1148/radiology.168.2.3260678
Yang, S. ; Rafla, S. ; Youssef, E. ; Selim, H. ; Salloum, N. ; Chuang, J. Y. / Changes in T-cell subsets after radiation therapy. In: Radiology. 1988 ; Vol. 168, No. 2. pp. 537-540.
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