Changes in sensorimotor-related thalamic diffusion properties and cerebrospinal fluid hydrodynamics predict gait responses to tap test in idiopathic normal-pressure hydrocephalus

Ping Huei Tsai, Yung Chieh Chen, Shih Wei Chiang, Teng Yi Huang, Ming Chung Chou, Hua Shan Liu, Hsiao Wen Chung, Giia Sheun Peng, Hsin I. Ma, Hung Wen Kao, Cheng Yu Chen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives: To compare diffusion tensor (DT)-derived indices from the thalamic nuclei and cerebrospinal fluid (CSF) hydrodynamic parameters for the prediction of gait responsiveness to the CSF tap test in early iNPH patients. Methods: In this study, 22 patients with iNPH and 16 normal controls were enrolled with the approval of an institutional review board. DT imaging and phase-contrast magnetic resonance imaging were performed in patients and controls to determine DT-related indices of the sensorimotor-related thalamic nuclei and CSF hydrodynamics. Gait performance was assessed in patients using gait scale before and after the tap test. The Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were applied to compare group differences between patients and controls and assess the predictive performance of gait responsiveness to the tap test in the patients. Results: Fractional anisotropy (FA) and axial diffusivity showed significant increases in the ventrolateral (VL) and ventroposterolateral (VPL) nuclei of the iNPH group compared with those of the control group (p < 0.05). The predictions of gait responsiveness of ventral thalamic FA alone (area under the ROC curve [AUC] < 0.8) significantly outperformed those of CSF hydrodynamics alone (AUC < 0.6). The AUC curve was elevated to 0.812 when the CSF peak systolic velocity and FA value were combined for the VPL nucleus, yielding the highest sensitivity (0.769) and specificity (0.778) to predict gait responses. Conclusions: Combined measurements of sensorimotor-related thalamic FA and CSF hydrodynamics can provide potential biomarkers for gait response to the CSF tap test in patients with iNPH. Key Points: • Ventrolateral and ventroposterolateral thalamic FA may predict gait responsiveness to tap test.• Thalamic neuroplasticity can be assessed through DTI in idiopathic normal-pressure hydrocephalus.• Changes in the CST associated with gait control could trigger thalamic neuroplasticity.• Activities of sensorimotor-related circuits could alter in patients with gait disturbance.• Management of patients with iNPH could be more appropriate.

Original languageEnglish
Pages (from-to)4504-4513
Number of pages10
JournalEuropean Radiology
Volume28
Issue number11
DOIs
Publication statusPublished - Nov 1 2018

Keywords

  • Diffusion tensor imaging
  • Gait
  • Hydrocephalus, normal pressure
  • Neuronal plasticity
  • Thalamus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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