Changes in prostaglandin E1 stimulation of glucose oxidation in rat adipocytes during maturation and aging

Wen Chang Chang, George S. Roth

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Prostaglandin E1 stimulates glucose oxidation in isolated rat adipocytes in a time and concentration dependent manner. Maximal stimulation requires 2 hours exposure to prostaglandin, although effects can be detected by 0.5 hours or earlier. In contrast to prostaglandin E1, prostaglandin F2α has essentially no effect on glucose oxidation. Maximal stimulation by prostaglandin E1 at all ages tested occurs at concentrations of 10-5 - 10-4M. Stimulation is greatest in cells of mature (10-12 month old) animals at 81 ± 9% above basal levels of glucose oxidation. This is to reduced to 48 ± 8% in cells of senescent (23-26 month old) animals, and at 23 ± 18% in cells of young (2-3 month old) rats is not significantly different from basal oxidation in most animals. These results are consistent with data for adipocytes and other cell types indicating that responsiveness to certain hormones is altered during maturation and aging.

Original languageEnglish
Pages (from-to)623-627
Number of pages5
JournalLife Sciences
Volume28
Issue number6
DOIs
Publication statusPublished - Feb 9 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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