Abstract
Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.
| Original language | English |
|---|---|
| Pages (from-to) | 149-157 |
| Number of pages | 9 |
| Journal | Prostaglandins, Leukotrienes and Medicine |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology
- Physiology
Cite this
Changes in arachidonate metabolism in aortas and platelets in aging rats. / Chang, Wen Chang; Tai, Hsin Hsiung.
In: Prostaglandins, Leukotrienes and Medicine, Vol. 12, No. 2, 1983, p. 149-157.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in arachidonate metabolism in aortas and platelets in aging rats
AU - Chang, Wen Chang
AU - Tai, Hsin Hsiung
PY - 1983
Y1 - 1983
N2 - Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.
AB - Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.
UR - http://www.scopus.com/inward/record.url?scp=0021046323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021046323&partnerID=8YFLogxK
U2 - 10.1016/0262-1746(83)90078-1
DO - 10.1016/0262-1746(83)90078-1
M3 - Article
C2 - 6417674
AN - SCOPUS:0021046323
VL - 12
SP - 149
EP - 157
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
SN - 0952-3278
IS - 2
ER -