Changes in arachidonate metabolism in aortas and platelets in aging rats

Wen Chang Chang, Hsin Hsiung Tai

Research output: Contribution to journalArticle

11 Citations (Scopus)


Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.

Original languageEnglish
Pages (from-to)149-157
Number of pages9
JournalProstaglandins, Leukotrienes and Medicine
Issue number2
Publication statusPublished - 1983
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology

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