Changes in arachidonate metabolism in aortas and platelets in aging rats

Wen Chang Chang; Hsin Hsiung Tai

doi:10.1016/0262-1746(83)90078-1

Changes in arachidonate metabolism in aortas and platelets in aging rats

Wen Chang Chang, Hsin Hsiung Tai

Research output: Contribution to journal › Article

11 Citations (Scopus)

Abstract

Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.

Original language	English
Pages (from-to)	149-157
Number of pages	9
Journal	Prostaglandins, Leukotrienes and Medicine
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/0262-1746(83)90078-1
Publication status	Published - 1983
Externally published	Yes

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ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology

Cite this

Chang, W. C., & Tai, H. H. (1983). Changes in arachidonate metabolism in aortas and platelets in aging rats. Prostaglandins, Leukotrienes and Medicine, 12(2), 149-157. https://doi.org/10.1016/0262-1746(83)90078-1

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AB - Prostacyclin formation by aortas, thromboxane biosynthesis and 12-lipoxygenase pathway in platelets as a function of age was investigated. Our results indicate an age-related decrease in prostacyclin production by aortas, while no significant change in thromboxane biosynthesis in platelets from mature (12 month old) to senescent (24 month old) rats was observed. Evidence is also presented indicating a decrease in 12-L-hydroperoxy-5,8,10,14-eicosatetraenoic acid (12-HPETE) peroxidase activity in platelets as a function of age.

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10.1016/0262-1746(83)90078-1