Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment

Kou-Gi Shyu, Cheuk-Sing Choy, Daniel Chung Lang Wang, Wei Chen Huang, Shyuan Yow Chen, Chien Hsun Chen, Che Tong Lin, Chao Chien Chang, Yung Kai Huang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Proinflammatory cytokines are key inflammatory mediators in periodontitis. This study aimed to investigate the relationship between proinflammatory cytokines in saliva and periodontal status. To investigate the usefulness of cytokines in the therapeutic approach for periodontal disease, the relationship between stimulated cytokine changes and the periodontitis treatment outcome was investigated in this study. Saliva was obtained from 22 patients diagnosed by dentists as having chronic periodontitis. The proinflammatory cytokine (interleukin-1 α (IL-1 α), interleukin-1 β (IL-1 β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor α (TNF-α), and tumor necrosis factor β (TNF-β)) levels were determined using a commercially available kit. The IL-1 β and IL-6 levels increased, whereas the TNF-β levels decreased with the severity of periodontitis (4 mm pocket percentage). Poststimulation IL-1 α, IL-6, and IL-8 levels were higher in patients who had an improved treatment outcome. The differences of IL-6 levels (cut point: 0.05 g/g) yielded a sensitivity and specificity of 90.0% and 81.82%, respectively, for predicting the periodontitis treatment outcome. Among the proinflammatory cytokines, stimulated IL-6 was an excellent marker for predicting the periodontitis treatment outcome.

Original languageEnglish
Article number289647
JournalScientific World Journal
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

saliva
Periodontitis
tumor
Interleukin-1
Interleukin-6
Cytokines
Interleukin-8
Saliva
Therapeutics
Tumor Necrosis Factor-alpha
Chronic Periodontitis
Periodontal Diseases
Dentists
necrosis
Sensitivity and Specificity
marker

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

Shyu, K-G., Choy, C-S., Wang, D. C. L., Huang, W. C., Chen, S. Y., Chen, C. H., ... Huang, Y. K. (2015). Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment. Scientific World Journal, 2015, [289647]. https://doi.org/10.1155/2015/289647

Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment. / Shyu, Kou-Gi; Choy, Cheuk-Sing; Wang, Daniel Chung Lang; Huang, Wei Chen; Chen, Shyuan Yow; Chen, Chien Hsun; Lin, Che Tong; Chang, Chao Chien; Huang, Yung Kai.

In: Scientific World Journal, Vol. 2015, 289647, 2015.

Research output: Contribution to journalArticle

Shyu, K-G, Choy, C-S, Wang, DCL, Huang, WC, Chen, SY, Chen, CH, Lin, CT, Chang, CC & Huang, YK 2015, 'Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment', Scientific World Journal, vol. 2015, 289647. https://doi.org/10.1155/2015/289647
Shyu, Kou-Gi ; Choy, Cheuk-Sing ; Wang, Daniel Chung Lang ; Huang, Wei Chen ; Chen, Shyuan Yow ; Chen, Chien Hsun ; Lin, Che Tong ; Chang, Chao Chien ; Huang, Yung Kai. / Change of scaling-induced proinflammatory cytokine on the clinical efficacy of periodontitis treatment. In: Scientific World Journal. 2015 ; Vol. 2015.
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