Change in T2∗ relaxation time of Hoffa fat pad correlates with histologic change in a rat anterior cruciate ligament transection model

Chao Ying Wang, Ping Huei Tsai, Tiing Yee Siow, Herng Sheng Lee, Yue Cune Chang, Yi Chih Hsu, Shih Wei Chiang, Ming Huang Lin, Hsiao Wen Chung, Guo Shu Huang

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Abstract

The Hoffa fat pad (infrapatellar fat pad) is a source of post-traumatic anterior knee pain, and Hoffa disease is a syndrome leading to chronic inflammation of the fat pad. Herein, change in T2∗ relaxation time of the fat pad was measured in a rodent anterior cruciate ligament transection (ACLX) model in order to (i) examine the causal relationship of anterior cruciate ligament (ACL) deficiency and Hoffa disease and (ii) demonstrate the feasibility of using T2∗ as an imaging biomarker to monitor disease progression. Three groups of male Sprague Dawley rats (n=6 each group), received either (i) no intervention; (ii) sham surgery at the right knee; or (iii) right ACLX. T2∗ relaxation time was measured and histology was examined in the Hoffa fat pad after surgery. At 13 and 18 weeks after surgery, T2∗ values were significantly higher in the right fat pad than the left (p

Original languageEnglish
Pages (from-to)1348-1355
Number of pages8
JournalJournal of Orthopaedic Research
Volume33
Issue number9
DOIs
Publication statusPublished - Sep 1 2015

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Keywords

  • anterior cruciate ligament
  • Hoffa disease
  • infrapatellar fat pad
  • MRI
  • relaxation time
  • T2

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Medicine(all)

Cite this

Wang, C. Y., Tsai, P. H., Siow, T. Y., Lee, H. S., Chang, Y. C., Hsu, Y. C., Chiang, S. W., Lin, M. H., Chung, H. W., & Huang, G. S. (2015). Change in T2∗ relaxation time of Hoffa fat pad correlates with histologic change in a rat anterior cruciate ligament transection model. Journal of Orthopaedic Research, 33(9), 1348-1355. https://doi.org/10.1002/jor.22914