Change in cerebral perfusion of patients with coma after treatment with right median nerve stimulation and hyperbaric oxygen

Jung Tung Liu, Jong Kang Lee, Yeu Sheng Tyan, Che Y. Liu, Tzer B. Lin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background. Survival rates after acute brain injury have improved, but persistent coma continues to be a major clinical problem. Objective. We analyzed changes in cerebral perfusion after treatment with right median nerve stimulation (MNS) or MNS with hyperbaric oxygen (MNS + HBO), two noninvasive therapies that have shown promise in this patient population. Methods. During the period this series of patients was treated, decision-makers were offered the option of MNS for six weeks (continued for maximum of three months if patient responded) or MNS + HBO (HBO given during the first six weeks of MNS). Results. Of 41 patients, 14 received MNS only and 27 received MNS + HBO. Pre- and posttreatment single photon emission computed tomography scans showed increased cerebral perfusion in 29 patients, with perfusion unchanged in nine patients and decreased in three patients. A total of 25 patients improved in one or more clinical measures, with 13 regaining consciousness. With univariate analysis, the odds ratio for improvement with MNS + HBO relative to MNS was 4.40 (95% confidence intervals: 1.06-18.36). Multivariate analysis indicated that MNS + HBO was significantly related to increased cerebral perfusion compared with MNS alone (odds ratio = 8.44, 95% confidence intervals: 1.34-52.97). Conclusion. The combination of MNS + HBO is more likely to result in improved cerebral perfusion than MNS alone. Randomized prospective trials evaluating MNS, especially with adjunct HBO, are needed to clarify clinical indications and most effective treatment schemes.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalNeuromodulation
Volume11
Issue number4
DOIs
Publication statusPublished - Nov 2008
Externally publishedYes

Fingerprint

Median Nerve
Coma
Perfusion
Oxygen
Therapeutics
Odds Ratio
Confidence Intervals
Single-Photon Emission-Computed Tomography
Consciousness
Brain Injuries

Keywords

  • Brain injury
  • Cerebral perfusion
  • Hyperbaric oxygen
  • Median nerve stimulation
  • Persistent coma
  • SPECT

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology

Cite this

Change in cerebral perfusion of patients with coma after treatment with right median nerve stimulation and hyperbaric oxygen. / Liu, Jung Tung; Lee, Jong Kang; Tyan, Yeu Sheng; Liu, Che Y.; Lin, Tzer B.

In: Neuromodulation, Vol. 11, No. 4, 11.2008, p. 296-301.

Research output: Contribution to journalArticle

Liu, Jung Tung ; Lee, Jong Kang ; Tyan, Yeu Sheng ; Liu, Che Y. ; Lin, Tzer B. / Change in cerebral perfusion of patients with coma after treatment with right median nerve stimulation and hyperbaric oxygen. In: Neuromodulation. 2008 ; Vol. 11, No. 4. pp. 296-301.
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