Change in cerebral perfusion of patients with coma after treatment with right median nerve stimulation and hyperbaric oxygen

Jung Tung Liu, Jong Kang Lee, Yeu Sheng Tyan, Che Yu Liu, Tzer Bin Lin

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background. Survival rates after acute brain injury have improved, but persistent coma continues to be a major clinical problem. Objective. We analyzed changes in cerebral perfusion after treatment with right median nerve stimulation (MNS) or MNS with hyperbaric oxygen (MNS + HBO), two noninvasive therapies that have shown promise in this patient population. Methods. During the period this series of patients was treated, decision-makers were offered the option of MNS for six weeks (continued for maximum of three months if patient responded) or MNS + HBO (HBO given during the first six weeks of MNS). Results. Of 41 patients, 14 received MNS only and 27 received MNS + HBO. Pre- and posttreatment single photon emission computed tomography scans showed increased cerebral perfusion in 29 patients, with perfusion unchanged in nine patients and decreased in three patients. A total of 25 patients improved in one or more clinical measures, with 13 regaining consciousness. With univariate analysis, the odds ratio for improvement with MNS + HBO relative to MNS was 4.40 (95% confidence intervals: 1.06-18.36). Multivariate analysis indicated that MNS + HBO was significantly related to increased cerebral perfusion compared with MNS alone (odds ratio = 8.44, 95% confidence intervals: 1.34-52.97). Conclusion. The combination of MNS + HBO is more likely to result in improved cerebral perfusion than MNS alone. Randomized prospective trials evaluating MNS, especially with adjunct HBO, are needed to clarify clinical indications and most effective treatment schemes.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
Issue number4
Publication statusPublished - Nov 2008
Externally publishedYes


  • Brain injury
  • Cerebral perfusion
  • Hyperbaric oxygen
  • Median nerve stimulation
  • Persistent coma

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine


Dive into the research topics of 'Change in cerebral perfusion of patients with coma after treatment with right median nerve stimulation and hyperbaric oxygen'. Together they form a unique fingerprint.

Cite this