Abstract
BACKGROUND/PURPOSE: To investigate the correlation between the CHADS2 score and risk of contrast-induced nephropathy (CIN), we conducted a retrospective study in patients who underwent elective percutaneous coronary intervention (PCI) and compared its accuracy with previous scoring systems.
METHODS: A total of 539 patients who underwent elective PCI were enrolled. Based on their underlying diseases, such as hypertension, diabetes, and kidney disease, CHADS2 score, R2CHADS2 score, and Mehran's risk score were calculated for each patient. Incidence of CIN was defined as a rise in serum creatinine >0.5 mg/dL or >25% increase in baseline within 48 hours after PCI. All study participants were followed up until October 2014, or until the occurrence of major adverse cardiovascular events (MACEs).
RESULTS: Overall, 55 cases (10.2%) of CIN and 90 cases (16.7%) of MACEs were identified after participants were followed up for 1.57 ± 1.46 years. The study cohort was divided into three groups according to CHADS2 scores: score 0, score 1-2, and score 3-6. In multivariate analysis, an increase of 1 point in the CHADS2 score was independently associated with a 37% increase in the risk of CIN (odds ratio, 1.37; 95% confidence interval, 1.00-1.87; p = 0.048) and a 49% increase in MACEs (hazard ratio, 1.49; 95% confidence interval, 1.18-1.88, p = 0.001). In pairwise comparison, the discriminatory performance of CHADS2 score was not inferior to either R2CHADS2 score (p = 0.226) or Mehran's risk score (p = 0.075).
CONCLUSION: CHADS2 score could be a simple and useful predictor for CIN in patients undergoing elective PCI.
| Original language | English |
|---|---|
| Pages (from-to) | 501-9 |
| Number of pages | 9 |
| Journal | Journal of the Formosan Medical Association = Taiwan yi zhi |
| Volume | 115 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2016 |
| Externally published | Yes |
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Keywords
- Acute Kidney Injury/chemically induced
- Aged
- Aged, 80 and over
- Contrast Media/adverse effects
- Coronary Angiography/adverse effects
- Coronary Artery Disease/surgery
- Creatinine/blood
- Female
- Humans
- Incidence
- Kaplan-Meier Estimate
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Percutaneous Coronary Intervention
- Predictive Value of Tests
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Severity of Illness Index
- Taiwan
Cite this
CHADS2 score predicts risk of contrast-induced nephropathy in stable coronary artery disease patients undergoing percutaneous coronary interventions. / Chou, Ruey-Hsing; Huang, Po-Hsun; Hsu, Chien-Yi; Leu, Hsin-Bang; Huang, Shao-Sung; Huang, Chin-Chou; Chen, Jaw-Wen; Lin, Shing-Jong.
In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 115, No. 7, 07.2016, p. 501-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - CHADS2 score predicts risk of contrast-induced nephropathy in stable coronary artery disease patients undergoing percutaneous coronary interventions
AU - Chou, Ruey-Hsing
AU - Huang, Po-Hsun
AU - Hsu, Chien-Yi
AU - Leu, Hsin-Bang
AU - Huang, Shao-Sung
AU - Huang, Chin-Chou
AU - Chen, Jaw-Wen
AU - Lin, Shing-Jong
N1 - Copyright © 2016. Published by Elsevier B.V.
PY - 2016/7
Y1 - 2016/7
N2 - BACKGROUND/PURPOSE: To investigate the correlation between the CHADS2 score and risk of contrast-induced nephropathy (CIN), we conducted a retrospective study in patients who underwent elective percutaneous coronary intervention (PCI) and compared its accuracy with previous scoring systems.METHODS: A total of 539 patients who underwent elective PCI were enrolled. Based on their underlying diseases, such as hypertension, diabetes, and kidney disease, CHADS2 score, R2CHADS2 score, and Mehran's risk score were calculated for each patient. Incidence of CIN was defined as a rise in serum creatinine >0.5 mg/dL or >25% increase in baseline within 48 hours after PCI. All study participants were followed up until October 2014, or until the occurrence of major adverse cardiovascular events (MACEs).RESULTS: Overall, 55 cases (10.2%) of CIN and 90 cases (16.7%) of MACEs were identified after participants were followed up for 1.57 ± 1.46 years. The study cohort was divided into three groups according to CHADS2 scores: score 0, score 1-2, and score 3-6. In multivariate analysis, an increase of 1 point in the CHADS2 score was independently associated with a 37% increase in the risk of CIN (odds ratio, 1.37; 95% confidence interval, 1.00-1.87; p = 0.048) and a 49% increase in MACEs (hazard ratio, 1.49; 95% confidence interval, 1.18-1.88, p = 0.001). In pairwise comparison, the discriminatory performance of CHADS2 score was not inferior to either R2CHADS2 score (p = 0.226) or Mehran's risk score (p = 0.075).CONCLUSION: CHADS2 score could be a simple and useful predictor for CIN in patients undergoing elective PCI.
AB - BACKGROUND/PURPOSE: To investigate the correlation between the CHADS2 score and risk of contrast-induced nephropathy (CIN), we conducted a retrospective study in patients who underwent elective percutaneous coronary intervention (PCI) and compared its accuracy with previous scoring systems.METHODS: A total of 539 patients who underwent elective PCI were enrolled. Based on their underlying diseases, such as hypertension, diabetes, and kidney disease, CHADS2 score, R2CHADS2 score, and Mehran's risk score were calculated for each patient. Incidence of CIN was defined as a rise in serum creatinine >0.5 mg/dL or >25% increase in baseline within 48 hours after PCI. All study participants were followed up until October 2014, or until the occurrence of major adverse cardiovascular events (MACEs).RESULTS: Overall, 55 cases (10.2%) of CIN and 90 cases (16.7%) of MACEs were identified after participants were followed up for 1.57 ± 1.46 years. The study cohort was divided into three groups according to CHADS2 scores: score 0, score 1-2, and score 3-6. In multivariate analysis, an increase of 1 point in the CHADS2 score was independently associated with a 37% increase in the risk of CIN (odds ratio, 1.37; 95% confidence interval, 1.00-1.87; p = 0.048) and a 49% increase in MACEs (hazard ratio, 1.49; 95% confidence interval, 1.18-1.88, p = 0.001). In pairwise comparison, the discriminatory performance of CHADS2 score was not inferior to either R2CHADS2 score (p = 0.226) or Mehran's risk score (p = 0.075).CONCLUSION: CHADS2 score could be a simple and useful predictor for CIN in patients undergoing elective PCI.
KW - Acute Kidney Injury/chemically induced
KW - Aged
KW - Aged, 80 and over
KW - Contrast Media/adverse effects
KW - Coronary Angiography/adverse effects
KW - Coronary Artery Disease/surgery
KW - Creatinine/blood
KW - Female
KW - Humans
KW - Incidence
KW - Kaplan-Meier Estimate
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Multivariate Analysis
KW - Odds Ratio
KW - Percutaneous Coronary Intervention
KW - Predictive Value of Tests
KW - Retrospective Studies
KW - Risk Assessment
KW - Risk Factors
KW - Severity of Illness Index
KW - Taiwan
U2 - 10.1016/j.jfma.2015.12.008
DO - 10.1016/j.jfma.2015.12.008
M3 - Article
C2 - 26830105
VL - 115
SP - 501
EP - 509
JO - Journal of the Formosan Medical Association
JF - Journal of the Formosan Medical Association
SN - 0929-6646
IS - 7
ER -