Cerebral hemodynamics and baroreflex sensitivity after carotid artery stenting

L. C. Hsu, F. C. Chang, T. B.J. Kuo, W. J. Wong, H. H. Hu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: The long-term hemodynamic effects of carotid angioplasty and stenting (CAS) are unclear. We performed a longitudinal study to investigate the variations in cerebral hemodynamics in patients undergoing CAS. Materials and methods: We performed prospective evaluation of 63 symptomatic male patients (19 patients had transient ischemic attack and 44 had minor stroke; mean age: 77.3 ± 6.3 years [range: 51-86]). The mean blood flow velocities (MBFV) and pulsatility index (PI) of the middle cerebral arteries (MCA) on both sides were evaluated using transcranial color-coded Doppler (TCCD) ultrasonography. Cardiac autonomic activities were evaluated by measuring baroreflex sensitivity (BRS). All parameters were measured at baseline prior to CAS and at 1, 3, 6, and 12 months after CAS. Results: The preoperative MBFV and PI of the ipsilateral MCA were significantly lower than those of the contralateral side. However, after CAS, MBFV in the ipsilateral MCA increased significantly until 2 weeks after stenting, after which the MBFV gradually decreased and remained stable for 1 year after CAS. Further, we observed a nonsignificant increase in MBFV in the contralateral MCA after CAS. In contrast to the MBFV, the BRS values decreased significantly 1 month after stenting and returned to baseline levels 6 months after CAS. Conclusions: Patients with CAS showed improved global cerebral hemodynamic status. However, the BRS did not normalize initially, and baseline value was achieved at 6 months after stenting.

Original languageEnglish
Pages (from-to)46-52
Number of pages7
JournalActa Neurologica Scandinavica
Volume127
Issue number1
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Baroreflex
Angioplasty
Carotid Arteries
Blood Flow Velocity
Hemodynamics
Middle Cerebral Artery
Doppler Color Ultrasonography
Transient Ischemic Attack
Longitudinal Studies
Stroke

Keywords

  • Baroreflex sensitivity
  • Carotid stenosis
  • Stent
  • Transcranial Doppler

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Cerebral hemodynamics and baroreflex sensitivity after carotid artery stenting. / Hsu, L. C.; Chang, F. C.; Kuo, T. B.J.; Wong, W. J.; Hu, H. H.

In: Acta Neurologica Scandinavica, Vol. 127, No. 1, 01.2013, p. 46-52.

Research output: Contribution to journalArticle

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