Cerebral columnar organization of the first nociceptive component induced by CO2 laser on the tail of the rat

Fu-Shan Jaw, Yu-Chieh Jill Kao, Chih-Ping Chen, Wen-Li Liao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The somatotopic map of the first nociceptive component in the primary somatosensory cortex (S1) is still unclear. In this study, a CO2 laser was applied to the tail of the rat to induce nociception without the interference from large myelinated (Aβ) fibers. Thus, only noxious fibers could be activated. Two-dimensional current-source-density analysis was used to analyze the evoked field potentials. Using this method, the nociceptive responses of Aδ-fibers in S1 were verified, and the somatotopic map of the first nociceptive component in S1 was identified. We found that whether light touch or laser-induced nociception was applied to the tail of the rat, the responsive topography in S1 was consistent. Discrimination of these two modalities was achieved vertically in the same column; the deeper layer represented the nociceptive response while the superficial layer encoded the response to light touch. This is quite different from that of a primate brain. © 2009 IBRO.
Original languageEnglish
Pages (from-to)945-950
Number of pages6
JournalNeuroscience
Volume158
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

Keywords

  • CO2 laser
  • cortex
  • current source density
  • evoked potentials
  • nociception
  • rat tail
  • carbon dioxide
  • afferent nerve group 1
  • animal experiment
  • article
  • brain mapping
  • controlled study
  • electric potential
  • evoked response
  • laser
  • male
  • nerve fiber Adelta
  • nonhuman
  • priority journal
  • rat
  • somatosensory cortex
  • tactile stimulation
  • Animals
  • Brain Mapping
  • Electroencephalography
  • Evoked Potentials, Somatosensory
  • Lasers, Gas
  • Male
  • Nerve Fibers, Myelinated
  • Neural Conduction
  • Pain
  • Pain Measurement
  • Physical Stimulation
  • Rats
  • Rats, Wistar
  • Reaction Time
  • Somatosensory Cortex
  • Tail

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