Ceramide in apoptotic signaling and anticancer therapy

C. F. Lin, Chia-Ling Chen, Yee-Shin Lin

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Ceramide, a product of sphingolipid metabolism, is generated in response to various stress stimuli, such as tumor necrosis factor-α, CD95 /Fas, chemotherapeutic agents, and irradiation. Ceramide may modulate the biochemical and cellular processes that lead to apoptosis. However, the mechanisms by which ceramide regulates apoptotic events are not fully defined. It is believed that the biological effect of ceramide depends on its concentration, the activation or differentiation status of the cell, and the time frame of action. Here, we discuss the metabolism and cell apoptotic signaling of ceramide. The involvement of protein kinases (i.e. P13K/Akt and GSK-3β) and protein phosphatases (i.e. PP1 and PP2A), Bcl-2 family proteins, mitochondrial damage, and caspase cascade activation are demonstrated. Further, ceramide and its derivatives have recently been incorporated into strategies for anticancer therapies. An understanding of the apoptotic signaling pathways mediated by ceramide may shed light on its potential for therapeutic intervention.

Original languageEnglish
Pages (from-to)1609-1616
Number of pages8
JournalCurrent Medicinal Chemistry
Volume13
Issue number14
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Ceramides
Metabolism
Therapeutics
Biochemical Phenomena
Chemical activation
Cell signaling
Glycogen Synthase Kinase 3
Sphingolipids
Phosphoprotein Phosphatases
Mitochondrial Proteins
Caspases
Protein Kinases
Cell Differentiation
Tumor Necrosis Factor-alpha
Irradiation
Apoptosis
Derivatives

Keywords

  • Anticancer
  • Apoptosis
  • Caspase
  • Ceramide
  • Mitochondria
  • Protein kinase
  • Protein phosphatase
  • Sphingolipid

ASJC Scopus subject areas

  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Pharmacology

Cite this

Ceramide in apoptotic signaling and anticancer therapy. / Lin, C. F.; Chen, Chia-Ling; Lin, Yee-Shin.

In: Current Medicinal Chemistry, Vol. 13, No. 14, 06.2006, p. 1609-1616.

Research output: Contribution to journalArticle

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