Central and peripheral hemodynamics in severe preeclampsia

Jenn Ming Yang, Yuh Cheng Yang, Kuo Gon Wang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. Doppler velocimetry, a new tool for measuring blood flow, vascular resistance, and central hemodynamics can be applied to monitor those patients at risk and provide therapeutic concepts for preeclampsia. This study was designed to use a Doppler velocimetry study to correlate the relationship between central hemodynamics, uteroplacental circulation, and the perinatal outcome in severe preeclampsia. Methods. Thirty-one patients with severe preeclampsia, not superimposed with any medical disorder and not on antihypertensive treatment prior to admission, were enrolled in this study. On admission, laboratory determination of the maternal blood chemistry and hematogram, together with a Doppler ultrasound study of the maternal hemodynamics, and umbilical and uterine arteries, were performed. Antihypertensive agents including hydralazine, atenolol, and labetolol were given according to the state of the maternal central hemodynamics. Data were collected on the general status of the patients, the results of the Doppler ultrasound study, and the perinatal outcome. Results. Patients were divided into three groups based on the systemic vascular resistance. The left ventricular function and cardiac index declined with increase in vascular resistance. The high-resistance group had a significantly high incidence of infants small for gestational age. Poor fetal growth in the high-resistance group could be attributed to the summation of underperfusion due to decreased uteroplacental blood flow and was frequently associated with maternal hemoconcentration. Conclusions. Although global vasospasm has been considered to be the basic pathophysiology of preeclampsia, the central hemodynamics varies between, and even in the same, patients. Regional vasospasm in the uteroplacental circulation occurs earlier than in the systemic circulation as a whole. A high cardiac-output in low systemic-vascular-resistance might compensate in those pregnancies with high uterine artery resistance to maintain adequate uteroplacental perfusion.

Original languageEnglish
Pages (from-to)120-126
Number of pages7
JournalActa Obstetricia et Gynecologica Scandinavica
Volume75
Issue number2
Publication statusPublished - 1996
Externally publishedYes

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Pre-Eclampsia
Vascular Resistance
Hemodynamics
Mothers
Placental Circulation
Doppler Ultrasonography
Uterine Artery
Rheology
Antihypertensive Agents
High Cardiac Output
Small for Gestational Age Infant
Labetalol
Hydralazine
Umbilical Arteries
Atenolol
Fetal Development
Left Ventricular Function
Perfusion
Outcome Assessment (Health Care)
Pregnancy

Keywords

  • Central hemodynamics
  • Doppler velocimetry
  • Severe preeclampsia

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Central and peripheral hemodynamics in severe preeclampsia. / Yang, Jenn Ming; Yang, Yuh Cheng; Wang, Kuo Gon.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 75, No. 2, 1996, p. 120-126.

Research output: Contribution to journalArticle

Yang, Jenn Ming ; Yang, Yuh Cheng ; Wang, Kuo Gon. / Central and peripheral hemodynamics in severe preeclampsia. In: Acta Obstetricia et Gynecologica Scandinavica. 1996 ; Vol. 75, No. 2. pp. 120-126.
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