Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report

M. M. Wu, W. F. Cheng, L. I. Hsu, C. J. Chen, H. Y. Chiou, T. C. Lee

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Heme oxygenase (HO)-1 is highly up-regulated by many stressful stimuli, including arsenic. A GT-repeat polymorphism in the HO-1 gene promoter can inversely modulate the levels of HO-1 induction. Long-term digestion of arsenic-contaminated drinking water may cause cancers of anatomic variety. We carried out this study to examine the correlation of HO-1 GT-repeat polymorphism with cancer risk in arsenic-exposed individuals during a 10-year follow-up. A total of 1,004 participants who had HO-1 genotyping available from two arsenicosis-endemic areas in Taiwan were included. Baseline characteristics derived from questionnaire interview were collected in 1988-1990 for the subjects of the BFD-endemic area and in 1996-1998 the subjects of the Lanyang Basin area. Allelic GT-repeats were categorized into short (S, 150 μg/L-year. Carriers of S/S genotype had a significantly increased risk of non-melanoma skin cancer [HR 3.05 (95% CI, 1.24-7.48), P = 0.015] as compared to those who carried L/L genotype for the entire subjects. Regarding liver and intrahepatic bile ducts cancer, carriers of S/S genotype also had a significantly increased risk [HR 4.14 (95% CI, 1.30-13.21), P = 0.016] when compared to those carried L/S genotype. We provided evidence that HO-1 gene variants may modify the carcinogenic effect of arsenic in a cell-type-dependent pattern.

Original languageEnglish
Title of host publicationOne Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PublisherCRC Press/Balkema
Pages519-520
Number of pages2
ISBN (Print)9781138001411
Publication statusPublished - 2014
Event5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina
Duration: May 11 2014May 16 2014

Other

Other5th International Congress on Arsenic in the Environment, As 2014
CountryArgentina
CityBuenos Aires
Period5/11/145/16/14

ASJC Scopus subject areas

  • Chemical Health and Safety

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    Wu, M. M., Cheng, W. F., Hsu, L. I., Chen, C. J., Chiou, H. Y., & Lee, T. C. (2014). Cell-type-dependent associations of heme oxygenase-1 GT-repeat polymorphisms with the cancer risk in arsenic-exposed individuals: A preliminary report. In One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment (pp. 519-520). CRC Press/Balkema.