Cell migration rate on poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymers and correlation with the material sliding angle

Shan Hui Hsu, Cheng Ming Tang, Jeng Jiann Chiu, Tien Chi Liao, Chu Chieh Lin, Hiroo Iwata

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The nanostructure of a biomaterial surface has strong influence on cell behavior. The migration of cells on nanostructured surfaces, however, has not been investigated so far. In this study, we used PCL/PEG diblock copolymers as model surfaces to examine the effect of nanoislands on migration of different cells, including fibroblasts and endothelial cells. The water sliding angle of the substrates was measured. The cell migration rate was examined under a real-time optical microscope. It was found that a greater cell migration rate correlated with the smaller sliding angle of the substrate.

Original languageEnglish
Pages (from-to)482-490
Number of pages9
JournalMacromolecular Bioscience
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 10 2007
Externally publishedYes

Keywords

  • Cell migration
  • Microphase separation
  • Nanotopography
  • PCL/PEG diblock copolymer
  • Sliding angle

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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