Cell and tissue tropism of enterovirus 71 and other enteroviruses infections

Jing Yi Lin, Shin Ru Shih

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Enterovirus 71 (EV71) is a member of Picornaviridae that causes mild and self-limiting hand, foot, and mouth disease (HFMD). However, EV71 infections can progress to polio-like paralysis, neurogenic pulmonary edema, and fatal encephalitis in infants and young children. Large EV71 outbreaks have been reported in Taiwan, China, Japan, Malaysia, Singapore, and Australia. This virus is considered a critical emerging public health threat. EV71 is an important crucial neurotropic enterovirus for which there is currently no effective antiviral drug or vaccine. The mechanism by which EV71 causes severe central nervous system complications remains unclear. The interaction between the virus and the host is vital for viral replication, virulence, and pathogenicity. SCARB2 or PSGL-1 receptor binding is the first step in the development of viral infections, and viral factors (e.g., 5′ UTR, VP1, 3C, 3D, 3′ UTR), host factors and environments (e.g., ITAFs, type I IFN) are also involved in viral infections. The tissue tropism and pathogenesis of viruses are determined by a combination of several factors. This review article provides a summary of host and virus factors affecting cell and tissue tropism and the pathogenesis of enteroviruses.

Original languageEnglish
Article number18
JournalJournal of Biomedical Science
Volume21
Issue number1
DOIs
Publication statusPublished - Mar 7 2014

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Enterovirus Infections
Tropism
Enterovirus
Viruses
Tissue
Virus Diseases
Virulence
5' Untranslated Regions
Neurology
3' Untranslated Regions
Public health
Hand, Foot and Mouth Disease
Picornaviridae
Antiviral Agents
Vaccines
Malaysia
Singapore
Poliomyelitis
Pulmonary Edema
Encephalitis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

Cite this

Cell and tissue tropism of enterovirus 71 and other enteroviruses infections. / Lin, Jing Yi; Shih, Shin Ru.

In: Journal of Biomedical Science, Vol. 21, No. 1, 18, 07.03.2014.

Research output: Contribution to journalArticle

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