Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation

Yang Kao Wang, Christopher S. Chen

Research output: Contribution to journalReview article

103 Citations (Scopus)

Abstract

Stem cells have been shown to have the potential to provide a source of cells for applications to tissue engineering and organ repair. The mechanisms that regulate stem cell fate, however, mostly remain unclear. Mesenchymal stem cells (MSCs) are multipotent progenitor cells that are isolated from bone marrow and other adult tissues, and can be differentiated into multiple cell lineages, such as bone, cartilage, fat, muscles and neurons. Although previous studies have focused intensively on the effects of chemical signals that regulate MSC commitment, the effects of physical/mechanical cues of the microenvironment on MSC fate determination have long been neglected. However, several studies provided evidence that mechanical signals, both direct and indirect, played important roles in regulating a stem cell fate. In this review, we summarize a number of recent studies on how cell adhesion and mechanical cues influence the differentiation of MSCs into specific lineages. Understanding how chemical and mechanical cues in the microenvironment orchestrate stem cell differentiation may provide new insights into ways to improve our techniques in cell therapy and organ repair.

Original languageEnglish
Pages (from-to)823-832
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume17
Issue number7
DOIs
Publication statusPublished - Jul 2013

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Keywords

  • Cell adhesion
  • Differentiation
  • Mechanical force
  • Mesenchymal stem cell
  • Microenvironment

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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