Cefepime MIC as a predictor of the extended-spectrum β-lactamase type in Klebsiella pneumoniae, Taiwan

Wen Liang Yu, Michael A. Pfaller, Patricia L. Winokur, Ronald N. Jones

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36 Citations (Scopus)

Abstract

To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum β-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.

Original languageEnglish
Pages (from-to)522-524
Number of pages3
JournalEmerging Infectious Diseases
Volume8
Issue number5
Publication statusPublished - 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology (medical)

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