CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Gilbert Aaron Lee; Nan Shih Liao

doi:10.1016/j.jmii.2020.06.005

CD8⁺CD122⁺ T cell homeostasis is controlled by different levels of IL-15 trans-presentation

Gilbert Aaron Lee, Nan Shih Liao

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

The homeostasis of CD8⁺CD122⁺ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8⁺CD122⁺ T cells homeostasis. We demonstrate that CD8⁺CD122⁺ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

Original language	English
Journal	Journal of Microbiology, Immunology and Infection
DOIs	https://doi.org/10.1016/j.jmii.2020.06.005
Publication status	Accepted/In press - 2020

Keywords

CD8CD122 T cell homeostasis
IL-15

ASJC Scopus subject areas

Immunology and Allergy
Immunology and Microbiology(all)
Microbiology (medical)
Infectious Diseases

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10.1016/j.jmii.2020.06.005

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title = "CD8+CD122+ T cell homeostasis is controlled by different levels of IL-15 trans-presentation",

abstract = "The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.",

keywords = "CD8CD122 T cell homeostasis, IL-15",

author = "Lee, {Gilbert Aaron} and Liao, {Nan Shih}",

note = "Funding Information: This work was supported by Academia Sinica ( 20-2d ) and Taipei Medical University Hospital ( 107TMUH SP-01 ). Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2020",

doi = "10.1016/j.jmii.2020.06.005",

language = "English",

journal = "Journal of Microbiology, Immunology and Infection",

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AU - Lee, Gilbert Aaron

AU - Liao, Nan Shih

N1 - Funding Information: This work was supported by Academia Sinica ( 20-2d ) and Taipei Medical University Hospital ( 107TMUH SP-01 ). Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020

Y1 - 2020

N2 - The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

AB - The homeostasis of CD8+CD122+ T cell requires IL-15 trans-presentation. We use Il15ra mutant mice and bone marrow chimeras to assess the role of IL-15 trans-presentation level in CD8+CD122+ T cells homeostasis. We demonstrate that CD8+CD122+ T cells require different levels of IL-15 trans-presentation to support their homeostasis.

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KW - IL-15

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