Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels

The Multicenter AIDS Cohort Study Group

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease.

Original languageEnglish
Pages (from-to)775-781
Number of pages7
JournalJournal of Infectious Diseases
Volume170
Issue number4
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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Lymphocyte Activation
HIV-1
HLA-DR Antigens
Virus Diseases
Survivors
Seroconversion
Flow Cytometry
Color
Lymphocytes
T-Lymphocytes
Membranes
Infection
Population

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion : Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels. / The Multicenter AIDS Cohort Study Group.

In: Journal of Infectious Diseases, Vol. 170, No. 4, 01.01.1994, p. 775-781.

Research output: Contribution to journalArticle

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title = "Cd8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of Hla-Dr+ Cd38 Cd8+ cells is associated with subsequent stable Cd4+ cell levels",
abstract = "Subsets of activated CD8+ lymphocytes defined by membrane expression of the activation antigens HLA-DR and CD38 were counted by three-color flow cytometry in homosexual men who subsequently became seropositive for human immunodeficiency virus type 1 (HIV). Profound CD8+ cell activation was seen in all subjects at seroconversion and 6 and 12 months later. The HLA-DR+ CD38+ CD8+ cell population, which has potent direct HIV cytotoxic T cell activity, was markedly elevated at seroconversion in all subjects. In some men, these levels remained elevated throughout the first year of infection. During the next 5 years, these men had stable CD4+ cell levels, whereas the others did not. Long-term survivors (seropositive for 9 years, >800 CD4+ cells/mm3) also had elevated levels of this subset, despite few other activated CD8+ cells. Thus, selective elevation of HLA-DR+ CD38 CD8+ cells was a marker of subsequent stable HIV disease.",
author = "{The Multicenter AIDS Cohort Study Group} and Giorgi, {J. V.} and Ho, {Hong Nerng} and Karim Hirji and Chou, {Chen Cheng} and Hultin, {Lance E.} and Sheryl O’rourke and Lawrence Park and Margolick, {Joseph B.} and John Ferbas and Phair, {John P.} and Saah, {A. J.} and H. Armenian and H. Farzadegan and N. Graham and {Mc Arthur}, J. and Margolick, {J. B.} and J. Palenicek and A. Mu{\~a}oz and D. Hoover and N. Galai and Jacobson, {L. P.} and L. Park and S. Piantadosi and S. Su and Phair, {J. P.} and K. Bauer and Chmiel, {J. S.} and B. Cohen and D. Variakojis and J. Wesch and Wolinsky, {S. M.} and R. Detels and Visscher, {B. R.} and I. Chen and J. Dudley and Fahey, {J. L.} and J. Ferbas and Giorgi, {J. V.} and O. Martinez-Maza and P. Nishanian and J. Taylor and J. Zack and Rinaldo, {C. R.} and Becker, {J. T.} and P. Gupta and M. Ho and L. Kingsley and L. Schrager and Kaslow, {R. A.} and {Van Raden}, {M. J.}",
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AU - Wesch, J.

AU - Wolinsky, S. M.

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