CD40 gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population

Ho Chang Kuo, Mei Chyn Chao, Yu Wen Hsu, Ying Chi Lin, Ying Hsien Huang, Hong Ren Yu, Ming Feng Hou, Chi Di Liang, Kuender D. Yang, Wei Chiao Chang, Chih Lu Wang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation. Methods. A total of 950 subjects (381KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P=0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P=0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population.

Original languageEnglish
Article number520865
JournalScientific World Journal
Volume2012
DOIs
Publication statusPublished - 2012
Externally publishedYes

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Mucocutaneous Lymph Node Syndrome
Polymorphism
lesion
Coronary Vessels
polymorphism
Genes
gene
Population
CD40 Ligand
Single Nucleotide Polymorphism
tagging
Systemic Vasculitis
Nucleotides
Association reactions
Disease Susceptibility
T-cells
Haplotypes
etiology
Coronary Artery Disease
Japan

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Medicine(all)

Cite this

CD40 gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population. / Kuo, Ho Chang; Chao, Mei Chyn; Hsu, Yu Wen; Lin, Ying Chi; Huang, Ying Hsien; Yu, Hong Ren; Hou, Ming Feng; Liang, Chi Di; Yang, Kuender D.; Chang, Wei Chiao; Wang, Chih Lu.

In: Scientific World Journal, Vol. 2012, 520865, 2012.

Research output: Contribution to journalArticle

Kuo, Ho Chang ; Chao, Mei Chyn ; Hsu, Yu Wen ; Lin, Ying Chi ; Huang, Ying Hsien ; Yu, Hong Ren ; Hou, Ming Feng ; Liang, Chi Di ; Yang, Kuender D. ; Chang, Wei Chiao ; Wang, Chih Lu. / CD40 gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population. In: Scientific World Journal. 2012 ; Vol. 2012.
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abstract = "Background. Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be reproduced by Taiwanese population. This study was conducted to investigate the CD40 polymorphism in KD and CAL formation. Methods. A total of 950 subjects (381KD patients and 569 controls) were investigated to identify 2 tagging single-nucleotide polymorphisms (tSNPs) of CD40 (rs4810485 and rs1535045) by using the TaqMan allelic discrimination assay. Results. A significant association was noted with regards to CD40 tSNPs (rs1535045) between controls and KD patients (P=0.0405, dominant model). In KD patients, polymorphisms of CD40 (rs4810485) showed significant association with CAL formation (P=0.0436, recessive model). Haplotype analysis did not yield more significant results between polymorphisms of CD40 and susceptibility/disease activity of KD. Conclusions. This study showed for the first time that polymorphisms of CD40 are associated with susceptibility to KD and CAL formation, in the Taiwanese population.",
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AU - Lin, Ying Chi

AU - Huang, Ying Hsien

AU - Yu, Hong Ren

AU - Hou, Ming Feng

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