CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis

You-Chen Chao, Heng-Cheng Chu, Wei-Kuo Chang, Hsin-Hung Huang, Tsai-Yuan Hsieh

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16 Citations (Scopus)

Abstract

Aim: To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different subpopulations. Methods: Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 (ALDH 2) in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver (n = 100), acute pancreatitis (n = 100), esophageal cancer (n = 82) and avascular necrosis of hip joint (AVN) (n = 53) and 194 non-alcoholic controls in a Chinese group. Results: The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer (0.79 vs 0.60, P
Original languageEnglish
Pages (from-to)6043-6048
Number of pages6
JournalWorld Journal of Gastroenterology
Volume11
Issue number38
Publication statusPublished - 2005
Externally publishedYes

Keywords

  • Alcoholic patients
  • CD14 promoter
  • Polymorphism
  • aldehyde dehydrogenase isoenzyme 2
  • CD14 antigen
  • adult
  • alcohol liver cirrhosis
  • alcoholic pancreatitis
  • article
  • avascular necrosis
  • Chinese
  • controlled study
  • DNA polymorphism
  • esophagus cancer
  • female
  • gene frequency
  • genotype
  • heterozygote
  • human
  • major clinical study
  • male
  • pathogenesis
  • polymerase chain reaction
  • prevalence
  • promoter region
  • restriction fragment length polymorphism
  • statistical analysis
  • Adult
  • Aged
  • Antigens, CD14
  • Asian Continental Ancestry Group
  • Base Sequence
  • Case-Control Studies
  • DNA
  • Female
  • Humans
  • Liver Cirrhosis, Alcoholic
  • Male
  • Middle Aged
  • Pancreatitis, Alcoholic
  • Polymorphism, Genetic
  • Promoter Regions (Genetics)
  • Taiwan

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