CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells

Chiung Yuan Ko, Ling Hua Chang, Yi Chao Lee, Esta Sterneck, Chun Pei Cheng, Shun Hua Chen, A. Mei Huang, Joseph T. Tseng, Ju Ming Wang

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ, NF-IL6β) is induced in many inflammation-related diseases, suggesting that CEBPD and its downstream targets may play central roles in these conditions. Neuropathological studies show that a neuroinflammatory response parallels the early stages of Alzheimer's disease (AD). However, the precise mechanistic correlation between inflammation and AD pathogenesis remains unclear. CEBPD is upregulated in the astrocytes of AD patients. Therefore, we asked if activation of astrocytic CEBPD could contribute to AD pathogenesis. In this report, a novel role of CEBPD in attenuating macrophage-mediated phagocytosis of damaged neuron cells was found. By global gene expression profiling, we identified the inflammatory marker pentraxin-3 (PTX3, TNFAIP5, TSG-14) as a CEBPD target in astrocytes. Furthermore, we demonstrate that PTX3 participates in the attenuation of macrophage-mediated phagocytosis of damaged neuron cells. This study provides the first demonstration of a role for astrocytic CEBPD and the CEBPD-regulated molecule PTX3 in the accumulation of damaged neurons, which is a hallmark of ADpathogenesis.

Original languageEnglish
JournalNeurobiology of Aging
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

Fingerprint

CCAAT-Enhancer-Binding Protein-delta
Phagocytosis
Macrophages
Neurons
Alzheimer Disease
Astrocytes
CCAAT-Enhancer-Binding Protein-beta
Inflammation
Gene Expression Profiling
Protein C

Keywords

  • Alzheimer's disease
  • CEBPD
  • Phagocytosis
  • PTX3

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Ageing
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. / Ko, Chiung Yuan; Chang, Ling Hua; Lee, Yi Chao; Sterneck, Esta; Cheng, Chun Pei; Chen, Shun Hua; Huang, A. Mei; Tseng, Joseph T.; Wang, Ju Ming.

In: Neurobiology of Aging, Vol. 33, No. 2, 02.2012.

Research output: Contribution to journalArticle

Ko, Chiung Yuan ; Chang, Ling Hua ; Lee, Yi Chao ; Sterneck, Esta ; Cheng, Chun Pei ; Chen, Shun Hua ; Huang, A. Mei ; Tseng, Joseph T. ; Wang, Ju Ming. / CCAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 2.
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