Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo

Yu Ting Cheng, Chi Hao Wu, Cheng Ying Ho, Gow Chin Yen

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P

Original languageEnglish
Pages (from-to)475-483
Number of pages9
JournalJournal of Nutritional Biochemistry
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

Keywords

  • Antioxidant enzymes
  • Catechin
  • COX
  • Gastric ulcer
  • GPx
  • GRd
  • GSH
  • GSSG
  • HO-1
  • Int-407 cells
  • Ketoprofen
  • LDH
  • MDA
  • NQO1
  • Nrf2
  • NSAID
  • NSAIDs
  • PG
  • ROS
  • SD rats
  • TBA
  • TSH

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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