Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo

Yu Ting Cheng, Chi Hao Wu, Cheng Ying Ho, Gow Chin Yen

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P

Original languageEnglish
Pages (from-to)475-483
Number of pages9
JournalJournal of Nutritional Biochemistry
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2013
Externally publishedYes

Fingerprint

Ketoprofen
Catechin
Gastric Mucosa
Mucous Membrane
Antioxidants
Polyphenols
Anti-Inflammatory Agents
Apigenin
Intestinal Diseases
Clinical Medicine
Phytochemicals
Pharmaceutical Preparations
Lipid Peroxidation
Ulcer
Medicine
Rats
Stomach
Lipids
Enzymes
In Vitro Techniques

Keywords

  • Antioxidant enzymes
  • Catechin
  • COX
  • Gastric ulcer
  • GPx
  • GRd
  • GSH
  • GSSG
  • HO-1
  • Int-407 cells
  • Ketoprofen
  • LDH
  • MDA
  • NQO1
  • Nrf2
  • NSAID
  • NSAIDs
  • PG
  • ROS
  • SD rats
  • TBA
  • TSH

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Biology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo. / Cheng, Yu Ting; Wu, Chi Hao; Ho, Cheng Ying; Yen, Gow Chin.

In: Journal of Nutritional Biochemistry, Vol. 24, No. 2, 02.2013, p. 475-483.

Research output: Contribution to journalArticle

Cheng, Yu Ting ; Wu, Chi Hao ; Ho, Cheng Ying ; Yen, Gow Chin. / Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo. In: Journal of Nutritional Biochemistry. 2013 ; Vol. 24, No. 2. pp. 475-483.
@article{ae499728c1354e99aaa2fd31541175f8,
title = "Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo",
abstract = "Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P",
keywords = "Antioxidant enzymes, Catechin, COX, Gastric ulcer, GPx, GRd, GSH, GSSG, HO-1, Int-407 cells, Ketoprofen, LDH, MDA, NQO1, Nrf2, NSAID, NSAIDs, PG, ROS, SD rats, TBA, TSH",
author = "Cheng, {Yu Ting} and Wu, {Chi Hao} and Ho, {Cheng Ying} and Yen, {Gow Chin}",
year = "2013",
month = "2",
doi = "10.1016/j.jnutbio.2012.01.010",
language = "English",
volume = "24",
pages = "475--483",
journal = "Journal of Nutritional Biochemistry",
issn = "0955-2863",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo

AU - Cheng, Yu Ting

AU - Wu, Chi Hao

AU - Ho, Cheng Ying

AU - Yen, Gow Chin

PY - 2013/2

Y1 - 2013/2

N2 - Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P

AB - Nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, are widely used in clinical medicine. However, these drugs may damage the gastrointestinal mucosa. Some reports have suggested that intestinal diseases, such as ulcers, are associated with lipid peroxidation and oxidative damage in the mucosa. Phytochemicals, such as polyphenols, are common dietary antioxidants that possess many beneficial characteristics, such as antioxidant and anti-inflammatory capabilities. The objective of this study was to investigate the protective effects of polyphenols on ketoprofen-induced oxidative damage in the gastrointestinal mucosa. We evaluated the effects of catechin, theaflavin, malvidin, cyanidin and apigenin on the activity of antioxidant enzymes in human intestinal-407 (Int-407) cells and rat primary gastric cells treated with ketoprofen. The results indicated that catechin significantly (P

KW - Antioxidant enzymes

KW - Catechin

KW - COX

KW - Gastric ulcer

KW - GPx

KW - GRd

KW - GSH

KW - GSSG

KW - HO-1

KW - Int-407 cells

KW - Ketoprofen

KW - LDH

KW - MDA

KW - NQO1

KW - Nrf2

KW - NSAID

KW - NSAIDs

KW - PG

KW - ROS

KW - SD rats

KW - TBA

KW - TSH

UR - http://www.scopus.com/inward/record.url?scp=84872776807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872776807&partnerID=8YFLogxK

U2 - 10.1016/j.jnutbio.2012.01.010

DO - 10.1016/j.jnutbio.2012.01.010

M3 - Article

C2 - 22704780

AN - SCOPUS:84872776807

VL - 24

SP - 475

EP - 483

JO - Journal of Nutritional Biochemistry

JF - Journal of Nutritional Biochemistry

SN - 0955-2863

IS - 2

ER -