Casuarinin from the bark of Terminalia arjuna induces apoptosis and cell cycle arrest in human breast adenocarcinoma MCF-7 cells

Po Lin Kuo, Ya Ling Hsu, Ta Chen Lin, Liang Tzung Lin, Jiunn Kae Chang, Chun Ching Lin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna L. (Combretaceae), was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. The results showed that casuarinin inhibited the proliferation of MCF-7 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis. An enzyme-linked immunosorbent assay showed that casuarinin increased the expression of p21/WAF1 concomitantly as the MCF-7 cells underwent G0/G1 arrest. An enhancement in Fas/APO-1 and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by casuarinin. Our study reports here for the first time that the induction of p21/WAF1 and the activity of Fas/Fas ligand apoptotic system may participate in the antiproliferative activity of casuarinin in MCF-7 cells.

Original languageEnglish
Pages (from-to)237-243
Number of pages7
JournalPlanta Medica
Volume71
Issue number3
DOIs
Publication statusPublished - Mar 2005
Externally publishedYes

Keywords

  • Apoptosis
  • Casuarinin
  • Combretaceae
  • Fas ligand
  • Fas/APO-1
  • P21/WAF1
  • p53
  • Terminalia arjuna

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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