Carvedilol modulates the expression of hypoxia-inducible factor-1α and vascular endothelial growth factor in a rat model of volume-overload heart failure

Kou-Gi Shyu, Ming Jen Lu, Hang Chang, Hsien Yi Sun, Bao Wei Wang, Peiliang Kuan

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: The use of β-blockers has emerged as a beneficial treatment for congestive heart failure. Hypoxia-inducible factor-1α (HIF-1α) is tightly regulated in the ventricular myocardium. However, the expression of HIF-1α in chronic heart failure resulting from volume overload and after treatment with β-blocker is little known. Methods and Results: To test the hypothesis that HIF-1α plays a role in the failing myocardium because of volume overload, an aorta-caval shunt was created for 4 weeks in adult Sprague-Dawley rats to induce volume-overload heart failure. Carvedilol at 50 mg/kg body weight per day after surgery was given. The heart weight and body weight ratio increased from 2.6 ± 0.3 in the sham group to 3.9 ± 0.7 (P

Original languageEnglish
Pages (from-to)152-159
Number of pages8
JournalJournal of Cardiac Failure
Volume11
Issue number2
DOIs
Publication statusPublished - Mar 2005

Keywords

  • β-blocker
  • Congestive heart failure
  • Gene expression
  • Growth factor

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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