Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells

Jaw Wen Chen; Feng Yen Lin; Yung Hsiang Chen; Tao Cheng Wu; Yuh Lien Chen; Shing Jong Lin

doi:10.1161/01.ATV.0000145016.69181.fa

Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells

Jaw Wen Chen, Feng Yen Lin, Yung Hsiang Chen, Tao Cheng Wu, Yuh Lien Chen, Shing Jong Lin

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Objective - We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. Methods and Results -Circulating MNCs were isolated from the peripheral blood of healthy subjects. Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. Carvedilol inhibited TNF-α-stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66.0±2.0% and 55.60±1.0% of control, P

Original language	English
Pages (from-to)	2075-2081
Number of pages	7
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	24
Issue number	11
DOIs	https://doi.org/10.1161/01.ATV.0000145016.69181.fa
Publication status	Published - Nov 2004
Externally published	Yes

Keywords

Antioxidant
Atherosclerosis
Carvedilol
Cell adhesion molecules
Endothelium

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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Chen, J. W., Lin, F. Y., Chen, Y. H., Wu, T. C., Chen, Y. L., & Lin, S. J. (2004). Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 24(11), 2075-2081. https://doi.org/10.1161/01.ATV.0000145016.69181.fa

Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. / Chen, Jaw Wen; Lin, Feng Yen; Chen, Yung Hsiang; Wu, Tao Cheng; Chen, Yuh Lien; Lin, Shing Jong.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 24, No. 11, 11.2004, p. 2075-2081.

Research output: Contribution to journal › Article › peer-review

Chen, JW, Lin, FY, Chen, YH, Wu, TC, Chen, YL & Lin, SJ 2004, 'Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 11, pp. 2075-2081. https://doi.org/10.1161/01.ATV.0000145016.69181.fa

Chen, Jaw Wen ; Lin, Feng Yen ; Chen, Yung Hsiang ; Wu, Tao Cheng ; Chen, Yuh Lien ; Lin, Shing Jong. / Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 ; Vol. 24, No. 11. pp. 2075-2081.

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AU - Lin, Shing Jong

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