Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells

Jaw Wen Chen, Feng Yen Lin, Yung Hsiang Chen, Tao Cheng Wu, Yuh Lien Chen, Shing Jong Lin

Research output: Contribution to journal › Article

39 Citations (Scopus)

Abstract

Objective - We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. Methods and Results -Circulating MNCs were isolated from the peripheral blood of healthy subjects. Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. Carvedilol inhibited TNF-α-stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66.0±2.0% and 55.60±1.0% of control, P

Original languageEnglish
Pages (from-to)2075-2081
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number11
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Fingerprint

Adhesiveness
Transcriptional Activation
Transcription Factors
Tumor Necrosis Factor-alpha
Prazosin
Propranolol
Adrenergic Receptors
Probucol
E-Selectin
Vascular Cell Adhesion Molecule-1
Atherosclerosis
Healthy Volunteers
Endothelial Cells
Antioxidants
carvedilol

Keywords

  • Antioxidant
  • Atherosclerosis
  • Carvedilol
  • Cell adhesion molecules
  • Endothelium

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. / Chen, Jaw Wen; Lin, Feng Yen; Chen, Yung Hsiang; Wu, Tao Cheng; Chen, Yuh Lien; Lin, Shing Jong.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 24, No. 11, 11.2004, p. 2075-2081.

Research output: Contribution to journal › Article

Chen, JW, Lin, FY, Chen, YH, Wu, TC, Chen, YL & Lin, SJ 2004, 'Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 24, no. 11, pp. 2075-2081. https://doi.org/10.1161/01.ATV.0000145016.69181.fa
Chen JW, Lin FY, Chen YH, Wu TC, Chen YL, Lin SJ. Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 Nov;24(11):2075-2081. https://doi.org/10.1161/01.ATV.0000145016.69181.fa
Chen, Jaw Wen ; Lin, Feng Yen ; Chen, Yung Hsiang ; Wu, Tao Cheng ; Chen, Yuh Lien ; Lin, Shing Jong. / Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2004 ; Vol. 24, No. 11. pp. 2075-2081.
@article{0e022be9e4ed4c9c8f53a26f575393e6,
title = "Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells",
abstract = "Objective - We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. Methods and Results -Circulating MNCs were isolated from the peripheral blood of healthy subjects. Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. Carvedilol inhibited TNF-α-stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66.0±2.0{\%} and 55.60±1.0{\%} of control, P",
keywords = "Antioxidant, Atherosclerosis, Carvedilol, Cell adhesion molecules, Endothelium",
author = "Chen, {Jaw Wen} and Lin, {Feng Yen} and Chen, {Yung Hsiang} and Wu, {Tao Cheng} and Chen, {Yuh Lien} and Lin, {Shing Jong}",
year = "2004",
month = "11",
doi = "10.1161/01.ATV.0000145016.69181.fa",
language = "English",
volume = "24",
pages = "2075--2081",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Carvedilol inhibits tumor necrosis factor-α-induced endothelial transcription factor activation, adhesion molecule expression, and adhesiveness to human mononuclear cells

AU - Chen, Jaw Wen

AU - Lin, Feng Yen

AU - Chen, Yung Hsiang

AU - Wu, Tao Cheng

AU - Chen, Yuh Lien

AU - Lin, Shing Jong

PY - 2004/11

Y1 - 2004/11

N2 - Objective - We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. Methods and Results -Circulating MNCs were isolated from the peripheral blood of healthy subjects. Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. Carvedilol inhibited TNF-α-stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66.0±2.0% and 55.60±1.0% of control, P

AB - Objective - We tested the hypothesis that carvedilol, a β-adrenoceptor and α-adrenoceptor antagonist with potent antioxidant property, could inhibit tumor necrosis factor-α (TNF-α)-induced endothelial adhesiveness to human mononuclear cells (MNCs), an early sign of atherogenesis. Methods and Results -Circulating MNCs were isolated from the peripheral blood of healthy subjects. Compared with control condition, pretreatment of carvedilol (10 μmol/L for 18 hours) or probucol (5 μmol/L for 18 hours), but not propanolol, prazosin, or both propanolol and prazosin significantly decreased TNF-α-stimulated adhesiveness of cultured human aortic endothelial cells (HAECs) to MNCs. Carvedilol inhibited TNF-α-stimulated endothelial vascular cell adhesion molecule-1 (VCAM-1) and E-selectin (66.0±2.0% and 55.60±1.0% of control, P

KW - Antioxidant

KW - Atherosclerosis

KW - Carvedilol

KW - Cell adhesion molecules

KW - Endothelium

UR - http://www.scopus.com/inward/record.url?scp=8344234111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8344234111&partnerID=8YFLogxK

U2 - 10.1161/01.ATV.0000145016.69181.fa

DO - 10.1161/01.ATV.0000145016.69181.fa

M3 - Article

C2 - 15374848

AN - SCOPUS:8344234111

VL - 24

SP - 2075

EP - 2081

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 11

ER -

Access to Document